BAIT
DRD4
D4DR
dopamine receptor D4
GO Process (24)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- activation of MAPK activity [IDA]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [IDA]
- adult locomotory behavior [ISS]
- arachidonic acid secretion [IDA]
- behavioral fear response [NAS]
- behavioral response to cocaine [ISS]
- behavioral response to ethanol [TAS]
- cellular calcium ion homeostasis [IC]
- dopamine metabolic process [IC]
- dopamine receptor signaling pathway [IDA]
- fear response [ISS]
- negative regulation of adenylate cyclase activity [IDA]
- negative regulation of cAMP biosynthetic process [IDA]
- negative regulation of protein secretion [IDA]
- negative regulation of voltage-gated calcium channel activity [IDA]
- positive regulation of dopamine uptake involved in synaptic transmission [IC]
- positive regulation of kinase activity [IDA]
- positive regulation of sodium:proton antiporter activity [IDA]
- regulation of circadian rhythm [ISS]
- regulation of dopamine metabolic process [ISS]
- regulation of inhibitory postsynaptic membrane potential [ISS]
- response to amphetamine [ISS]
- response to histamine [IDA]
- social behavior [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CLIC6
CLIC1L
chloride intracellular channel 6
GO Process (0)
GO Function (0)
GO Component (1)
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors.
To identify proteins interacting with the C-terminal cytoplasmic tail of the dopamine D(3) receptor (D(3)R), we used the two-hybrid system to screen a rat brain cDNA library. We isolated three partial cDNAs encoding, respectively, for the MUPP1 multi-PDZ protein, for the N-terminal region of radixin, for GIPC and for a 160-amino acid open reading frame sharing high homology with the ... [more]
Brain Res. Mol. Brain Res. Sep. 10, 2003; 117(1);47-57 [Pubmed: 14499480]
Throughput
- Low Throughput
Curated By
- BioGRID