LIMK1
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- Rho protein signal transduction [TAS]
- actin cytoskeleton organization [TAS]
- axon guidance [TAS]
- innate immune response [TAS]
- negative regulation of ubiquitin-protein transferase activity [IDA]
- nervous system development [TAS]
- positive regulation of actin filament bundle assembly [IDA]
- positive regulation of axon extension [ISS]
- protein phosphorylation [IDA, IMP]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BMPR2
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IMP, ISS, TAS]
- activin receptor signaling pathway [TAS]
- anterior/posterior pattern specification [ISS]
- artery development [ISS]
- blood vessel remodeling [ISS]
- cellular response to starvation [IEP]
- chondrocyte development [IMP]
- lung alveolus development [ISS]
- lymphangiogenesis [ISS]
- lymphatic endothelial cell differentiation [ISS]
- mesoderm formation [ISS]
- negative regulation of DNA biosynthetic process [IMP]
- negative regulation of cell growth [IDA]
- negative regulation of chondrocyte proliferation [IMP]
- negative regulation of systemic arterial blood pressure [IMP]
- negative regulation of vasoconstriction [ISS]
- positive regulation of BMP signaling pathway [IMP]
- positive regulation of bone mineralization [IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of epithelial cell migration [IDA]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- regulation of cell proliferation [IMP]
- regulation of lung blood pressure [IMP, ISS]
- retina vasculature development in camera-type eye [ISS]
- transcription from RNA polymerase II promoter [IMP]
- transmembrane receptor protein serine/threonine kinase signaling pathway [IDA]
- vascular endothelial growth factor receptor signaling pathway [ISS]
- venous blood vessel development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1.
Bone morphogenetic proteins (BMPs) regulate multiple cellular processes, including cell differentiation and migration. Their signals are transduced by the kinase receptors BMPR-I and BMPR-II, leading to Smad transcription factor activation via BMPR-I. LIM kinase (LIMK) 1 is a key regulator of actin dynamics as it phosphorylates and inactivates cofilin, an actin depolymerizing factor. During a search for LIMK1-interacting proteins, we ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LIMK1 BMPR2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID