CD63
Gene Ontology Biological Process
- cell migration [ISO]
- cell-matrix adhesion [ISO]
- cellular protein localization [ISO]
- endosome to melanosome transport [ISO]
- epithelial cell differentiation [ISO]
- negative regulation of epithelial cell migration [ISO]
- pigment cell differentiation [IMP]
- pigment granule maturation [ISO]
- pigmentation [IMP]
- positive regulation of cell adhesion [ISO]
- positive regulation of endocytosis [ISO]
- positive regulation of integrin-mediated signaling pathway [ISO]
- positive regulation of receptor internalization [ISO]
- regulation of rubidium ion transport [ISO]
- regulation of vascular endothelial growth factor signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell surface [ISO]
- cytoplasm [ISO]
- endosome lumen [ISO]
- endosome membrane [ISO]
- extracellular vesicular exosome [ISO]
- intrinsic component of plasma membrane [ISO]
- late endosome [IDA]
- late endosome membrane [ISO]
- lysosomal membrane [ISO]
- lysosome [IDA, ISO]
- multivesicular body, internal vesicle [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
ATP12A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
CD63 interacts with the carboxy terminus of the colonic H+-K+-ATPase to decrease [corrected] plasma membrane localization and 86Rb+ uptake.
The carboxy terminus (CT) of the colonic H(+)-K(+)-ATPase is required for stable assembly with the beta-subunit, translocation to the plasma membrane, and efficient function of the transporter. To identify protein-protein interactions involved in the localization and function of HKalpha(2), we selected 84 amino acids in the CT of the alpha-subunit of mouse colonic H(+)-K(+)-ATPase (CT-HKalpha(2)) as the bait in a ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ATP12A CD63 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID