GCN5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RTS1
Gene Ontology Biological Process
- cellular bud neck septin ring organization [IGI, IMP]
- cellular protein localization [IMP]
- establishment of protein localization to chromosome [IMP]
- meiotic sister chromatid cohesion, centromeric [IMP]
- mitotic spindle orientation checkpoint [IGI]
- protein dephosphorylation [IDA, IMP]
- septin ring disassembly [IMP]
- sister chromatid biorientation [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
Connecting GCN5's centromeric SAGA to the mitotic tension-sensing checkpoint.
Multiple interdependent mechanisms ensure faithful segregation of chromosomes during cell division. Among these, the spindle assembly checkpoint monitors attachment of spindle microtubules to the centromere of each chromosome, whereas the tension-sensing checkpoint monitors the opposing forces between sister chromatid centromeres for proper biorientation. We report here a new function for the deeply conserved Gcn5 acetyltransferase in the centromeric localization of ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
- phenotype: cell cycle progression (APO:0000253)
- phenotype: chromosome segregation (APO:0000208)
- phenotype: resistance to chemicals (APO:0000087)
Additional Notes
- Overexpression of RTS1 rescues late cell cycle and chromosome segregation-related gcn5 phenotypes
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
GCN5 RTS1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 2202289 | |
GCN5 RTS1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 2202301 | |
GCN5 RTS1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 2202302 |
Curated By
- BioGRID