TOR2
Gene Ontology Biological Process
- TOR signaling [IC, IMP]
- actin filament reorganization involved in cell cycle [TAS]
- cytoskeleton organization [IMP]
- establishment or maintenance of actin cytoskeleton polarity [IMP]
- negative regulation of autophagy [IGI]
- positive regulation of Rho guanyl-nucleotide exchange factor activity [IGI, IMP]
- positive regulation of Rho protein signal transduction [IGI, IMP]
- positive regulation of endocytosis [IMP]
- regulation of cell cycle [TAS]
- regulation of cell growth [TAS]
- ribosome biogenesis [IMP]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BEM2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Probing the membrane environment of the TOR kinases reveals functional interactions between TORC1, actin, and membrane trafficking in Saccharomyces cerevisiae.
The TOR kinases are regulators of growth in eukaryotic cells that assemble into two distinct protein complexes, TORC1 and TORC2, where TORC1 is inhibited by the antibiotic rapamycin. Present models favor a view wherein TORC1 regulates cell mass accumulation, and TORC2 regulates spatial aspects of growth, including organization of the actin cytoskeleton. Here, we demonstrate that in yeast both TORC1 ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TOR2 BEM2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1882 | BioGRID | 393470 | |
| TOR2 BEM2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2461 | BioGRID | 1997414 |
Curated By
- BioGRID