BAIT
TLR9
CD289, UNQ5798/PRO19605
toll-like receptor 9
GO Process (33)
GO Function (2)
GO Component (13)
Gene Ontology Biological Process
- I-kappaB phosphorylation [IDA]
- defense response to Gram-negative bacterium [IMP]
- defense response to bacterium [NAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- maintenance of gastrointestinal epithelium [ISS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of interleukin-6 production [ISS]
- negative regulation of interleukin-8 production [IDA]
- negative regulation of toll-like receptor signaling pathway [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of JNK cascade [IC]
- positive regulation of JUN kinase activity [IDA]
- positive regulation of NF-kappaB import into nucleus [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of chemokine production [IDA]
- positive regulation of inflammatory response [IC]
- positive regulation of interferon-alpha biosynthetic process [IDA]
- positive regulation of interferon-beta biosynthetic process [IDA]
- positive regulation of interferon-beta production [ISS]
- positive regulation of interferon-gamma biosynthetic process [IDA]
- positive regulation of interleukin-10 production [ISS]
- positive regulation of interleukin-12 production [ISS]
- positive regulation of interleukin-18 production [ISS]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of nitric-oxide synthase biosynthetic process [ISS]
- positive regulation of toll-like receptor signaling pathway [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of tumor necrosis factor production [ISS]
- response to molecule of bacterial origin [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [TAS]
- apical plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- cytoplasm [IDA]
- early phagosome [ISS]
- endolysosome membrane [TAS]
- endoplasmic reticulum [ISS]
- endoplasmic reticulum membrane [TAS]
- endosome [ISS]
- endosome membrane [TAS]
- extracellular region [NAS]
- lysosome [ISS]
- plasma membrane [IDA]
Homo sapiens
PREY
PAK2
PAK65, PAKgamma
p21 protein (Cdc42/Rac)-activated kinase 2
GO Process (24)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell costimulation [TAS]
- T cell receptor signaling pathway [TAS]
- apoptotic process [TAS]
- axon guidance [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- innate immune response [TAS]
- intracellular signal transduction [IBA]
- mitotic cell cycle [IBA]
- negative regulation of apoptotic process [IMP, TAS]
- negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [IDA]
- negative regulation of protein kinase activity [TAS]
- peptidyl-serine phosphorylation [IDA]
- phosphorylation [IDA]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of protein tyrosine kinase activity [IDA]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of apoptotic process [TAS]
- regulation of defense response to virus by virus [TAS]
- signal transduction [TAS]
- signal transduction by phosphorylation [IBA]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
E-cadherin expression on multiple myeloma cells activates tumor-promoting properties in plasmacytoid DCs.
Plasmacytoid dendritic cells (pDCs) play a key role in antiviral responses by producing type-1 IFNs. However, recent studies showed that pDCs induce immune suppression and promote tumor growth in human ovarian cancer and myeloma. The molecular mechanisms underlying pDC acquisition of these properties are unknown. Here we show that human pDCs activated by CpG inhibited growth and induced apoptosis in ... [more]
J. Clin. Invest. Nov. 01, 2018; 128(11);4821-4831 [Pubmed: 30277474]
Throughput
- High Throughput
Curated By
- BioGRID