GRB2
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- aging [ISO]
- anatomical structure formation involved in morphogenesis [IMP]
- branching involved in labyrinthine layer morphogenesis [IMP]
- cell differentiation [IMP]
- cellular response to ionizing radiation [ISO]
- fibroblast growth factor receptor signaling pathway [IGI]
- insulin receptor signaling pathway [ISO]
- positive regulation of actin filament polymerization [IGI]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of signal transduction [IDA]
- protein heterooligomerization [ISO]
- receptor internalization [ISO]
- regulation of MAPK cascade [IGI]
- signal transduction in response to DNA damage [ISO]
Gene Ontology Molecular Function- SH3 domain binding [ISO]
- SH3/SH2 adaptor activity [IDA]
- ephrin receptor binding [IPI, ISO]
- epidermal growth factor receptor binding [ISO]
- identical protein binding [ISO]
- insulin receptor substrate binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [ISO]
- phosphotyrosine binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [IPI]
- SH3 domain binding [ISO]
- SH3/SH2 adaptor activity [IDA]
- ephrin receptor binding [IPI, ISO]
- epidermal growth factor receptor binding [ISO]
- identical protein binding [ISO]
- insulin receptor substrate binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [ISO]
- phosphotyrosine binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [IPI]
Gene Ontology Cellular Component
PDGFRB
Gene Ontology Biological Process
- adrenal gland development [IGI]
- aorta morphogenesis [IGI]
- cardiac myofibril assembly [IGI]
- cardiac vascular smooth muscle cell differentiation [TAS]
- cell chemotaxis [ISO]
- cell migration [ISO]
- cell migration involved in coronary angiogenesis [IMP]
- cell migration involved in vasculogenesis [IMP]
- cellular response to platelet-derived growth factor stimulus [ISO]
- glycosaminoglycan biosynthetic process [ISO]
- hemopoiesis [IMP]
- in utero embryonic development [IMP]
- intracellular signal transduction [ISO]
- kidney development [IMP]
- metanephric glomerular capillary formation [IGI]
- metanephric glomerular mesangial cell proliferation involved in metanephros development [IMP]
- metanephric mesenchymal cell migration [ISO]
- negative regulation of apoptotic process [ISO]
- nitrogen compound metabolic process [IMP]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- phosphatidylinositol metabolic process [ISO]
- phosphatidylinositol-mediated signaling [ISO]
- phosphorylation [IMP]
- platelet-derived growth factor receptor signaling pathway [IMP, ISO]
- platelet-derived growth factor receptor-beta signaling pathway [ISO]
- positive regulation of DNA biosynthetic process [IMP]
- positive regulation of ERK1 and ERK2 cascade [IDA, IMP, ISO]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of calcium ion import [IMP]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [ISO]
- positive regulation of chemotaxis [IDA]
- positive regulation of collagen biosynthetic process [ISO]
- positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [IMP]
- positive regulation of mitosis [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of phospholipase C activity [ISO]
- positive regulation of phosphoprotein phosphatase activity [ISO]
- positive regulation of reactive oxygen species metabolic process [IMP]
- positive regulation of smooth muscle cell migration [IGI, IMP, ISO]
- positive regulation of smooth muscle cell proliferation [IMP, ISO]
- protein autophosphorylation [IDA, ISO]
- regulation of actin cytoskeleton organization [IGI]
- regulation of peptidyl-tyrosine phosphorylation [IMP]
- retina vasculature development in camera-type eye [IGI, IMP]
- signal transduction [IDA, ISO]
- skeletal system morphogenesis [IMP]
- smooth muscle cell chemotaxis [IGI]
- smooth muscle tissue development [IMP]
- tissue homeostasis [IMP]
Gene Ontology Molecular Function- kinase activity [IMP]
- phosphatidylinositol 3-kinase binding [ISO]
- platelet-derived growth factor beta-receptor activity [ISO]
- platelet-derived growth factor binding [ISO, TAS]
- platelet-derived growth factor receptor binding [ISO]
- platelet-derived growth factor-activated receptor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [ISO]
- receptor binding [IPI, ISO]
- signal transducer activity [IDA]
- vascular endothelial growth factor binding [ISO]
- kinase activity [IMP]
- phosphatidylinositol 3-kinase binding [ISO]
- platelet-derived growth factor beta-receptor activity [ISO]
- platelet-derived growth factor binding [ISO, TAS]
- platelet-derived growth factor receptor binding [ISO]
- platelet-derived growth factor-activated receptor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [ISO]
- receptor binding [IPI, ISO]
- signal transducer activity [IDA]
- vascular endothelial growth factor binding [ISO]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase.
Autophosphorylated growth factor receptors provide binding sites for the src homology 2 domains of intracellular signaling molecules. In response to epidermal growth factor (EGF), the activated EGF receptor binds to a complex containing the signaling protein GRB2 and the Ras guanine nucleotide-releasing factor Sos, leading to activation of the Ras signaling pathway. We have investigated whether the platelet-derived growth factor ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GRB2 PDGFRB | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID