BAIT
EIF4B
EIF-4B, PRO1843
eukaryotic translation initiation factor 4B
GO Process (10)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- insulin receptor signaling pathway [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [TAS]
- nuclear-transcribed mRNA poly(A) tail shortening [TAS]
- regulation of translational initiation [TAS]
- translation [TAS]
- translational initiation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SNRPD3
SMD3, Sm-D3
small nuclear ribonucleoprotein D3 polypeptide 18kDa
GO Process (10)
GO Function (4)
GO Component (14)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- RNA splicing [TAS]
- gene expression [TAS]
- histone mRNA metabolic process [TAS]
- mRNA 3'-end processing [TAS]
- mRNA splicing, via spliceosome [IC, TAS]
- ncRNA metabolic process [TAS]
- spliceosomal snRNP assembly [IDA, TAS]
- termination of RNA polymerase II transcription [TAS]
- transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SMN-Sm protein complex [IDA]
- U1 snRNP [IDA]
- U12-type spliceosomal complex [IDA]
- U4 snRNP [IDA]
- U7 snRNP [IDA]
- catalytic step 2 spliceosome [IDA]
- cytoplasm [IDA]
- cytosol [IDA, TAS]
- extracellular vesicular exosome [IDA]
- methylosome [IDA]
- nucleoplasm [IDA, TAS]
- pICln-Sm protein complex [IDA]
- small nuclear ribonucleoprotein complex [TAS]
- spliceosomal complex [TAS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1.
Controlling translation initiation is an efficient way to regulate gene expression at the post-transcriptional level. However, current knowledge regarding regulatory proteins and their modes of controlling translation initiation is still limited. In this study, we employed tandem affinity purification and mass spectrometry to screen for unknown proteins associated with the translation initiation machinery. Ubiquitin specific peptidase 9, X-linked (USP9X), was ... [more]
Nucleic Acids Res. Jan. 25, 2018; 46(2);823-839 [Pubmed: 29228324]
Throughput
- High Throughput
Curated By
- BioGRID