SYK
Gene Ontology Biological Process
- B cell receptor signaling pathway [IBA, ISS]
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- adaptive immune response [IBA, ISS]
- blood coagulation [TAS]
- blood vessel morphogenesis [ISS]
- cell proliferation [TAS]
- cellular response to molecule of fungal origin [ISS]
- defense response to bacterium [ISS]
- inflammatory response [IBA]
- innate immune response [IBA, ISS, TAS]
- integrin-mediated signaling pathway [ISS, NAS]
- leukocyte activation involved in immune response [ISS]
- leukocyte cell-cell adhesion [IDA]
- lymph vessel development [ISS]
- macrophage activation involved in immune response [IBA, ISS]
- neutrophil activation involved in immune response [IBA, ISS]
- neutrophil chemotaxis [IDA]
- organ morphogenesis [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- platelet activation [TAS]
- positive regulation of B cell differentiation [IBA]
- positive regulation of alpha-beta T cell proliferation [IBA]
- positive regulation of bone resorption [ISS]
- positive regulation of cell adhesion mediated by integrin [IBA, ISS]
- positive regulation of mast cell degranulation [IBA]
- protein phosphorylation [ISS]
- regulation of ERK1 and ERK2 cascade [ISS]
- regulation of arachidonic acid secretion [ISS]
- regulation of neutrophil degranulation [ISS]
- regulation of phagocytosis [ISS]
- regulation of platelet activation [ISS]
- regulation of platelet aggregation [IBA, ISS]
- regulation of sequence-specific DNA binding transcription factor activity [IMP]
- regulation of superoxide anion generation [ISS]
- serotonin secretion by platelet [ISS]
- transcription factor import into nucleus [IMP]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
COASY
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
CoA Synthase is phosphorylated on tyrosines in mammalian cells, interacts with and is dephosphorylated by Shp2PTP.
CoA Synthase (CoASy, 4'-phosphopantetheine adenylyltransferase/dephospho-CoA kinase) mediates two final stages of de novo coenzyme A (CoA) biosynthesis in higher eukaryotes. Unfortunately very little is known about regulation of this important metabolic pathway. In this study, we demonstrate that CoASy interacts in vitro with Src homology-2 (SH2) domains of a number of signaling proteins, including Src homology-2 domains containing protein tyrosine ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID