BAIT
ANAPC4
APC4
anaphase promoting complex subunit 4
GO Process (7)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- mitotic cell cycle [TAS]
- mitotic spindle assembly checkpoint [TAS]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- protein K11-linked ubiquitination [IDA]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
KIF2C
CT139, KNSL6, MCAK, RP11-269F19.1
kinesin family member 2C
GO Process (12)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- ATP catabolic process [IBA]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- blood coagulation [TAS]
- cell proliferation [TAS]
- establishment or maintenance of microtubule cytoskeleton polarity [IMP]
- metabolic process [IBA, TAS]
- microtubule depolymerization [IDA, IMP]
- microtubule-based movement [IBA, TAS]
- mitotic cell cycle [TAS]
- mitotic metaphase plate congression [IMP]
- mitotic nuclear division [TAS]
- regulation of chromosome segregation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
SUMO targets the APC/C to regulate transition from metaphase to anaphase.
Signal transduction by small ubiquitin-like modifier (SUMO) regulates a myriad of nuclear processes. Here we report on the role of SUMO in mitosis in human cell lines. Knocking down the SUMO conjugation machinery results in a delay in mitosis and defects in mitotic chromosome separation. Searching for relevant SUMOylated proteins in mitosis, we identify the anaphase-promoting complex/cyclosome (APC/C), a master ... [more]
Nat Commun Dec. 16, 2017; 9(1);1119 [Pubmed: 29549242]
Throughput
- High Throughput
Curated By
- BioGRID