PIK3R1
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- T cell costimulation [TAS]
- T cell receptor signaling pathway [TAS]
- blood coagulation [TAS]
- cellular glucose homeostasis [ISS]
- cellular response to insulin stimulus [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- growth hormone receptor signaling pathway [IDA]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- insulin-like growth factor receptor signaling pathway [IDA, IPI]
- leukocyte migration [TAS]
- negative regulation of apoptotic process [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol 3-kinase signaling [IDA]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol phosphorylation [ISS]
- phosphatidylinositol-mediated signaling [TAS]
- phospholipid metabolic process [TAS]
- platelet activation [TAS]
- positive regulation of RNA splicing [IMP]
- positive regulation of endoplasmic reticulum unfolded protein response [IMP]
- positive regulation of establishment of protein localization to plasma membrane [ISS]
- positive regulation of glucose import [ISS]
- positive regulation of transcription factor import into nucleus [IDA, ISS]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISS]
- protein stabilization [IDA]
- regulation of phosphatidylinositol 3-kinase activity [ISS]
- response to endoplasmic reticulum stress [IDA, ISS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- ErbB-3 class receptor binding [IDA]
- insulin binding [IDA]
- insulin receptor binding [IPI]
- insulin receptor substrate binding [ISS]
- insulin-like growth factor receptor binding [IPI]
- neurotrophin TRKA receptor binding [IPI]
- phosphatidylinositol 3-kinase binding [ISS]
- phosphatidylinositol 3-kinase regulator activity [ISS]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- transcription factor binding [IPI]
- transmembrane receptor protein tyrosine kinase adaptor activity [ISS]
- ErbB-3 class receptor binding [IDA]
- insulin binding [IDA]
- insulin receptor binding [IPI]
- insulin receptor substrate binding [ISS]
- insulin-like growth factor receptor binding [IPI]
- neurotrophin TRKA receptor binding [IPI]
- phosphatidylinositol 3-kinase binding [ISS]
- phosphatidylinositol 3-kinase regulator activity [ISS]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- transcription factor binding [IPI]
- transmembrane receptor protein tyrosine kinase adaptor activity [ISS]
Gene Ontology Cellular Component
FLT1
Gene Ontology Biological Process
- blood vessel morphogenesis [ISS]
- cell migration [IMP]
- cellular response to vascular endothelial growth factor stimulus [IDA]
- embryonic morphogenesis [ISS]
- monocyte chemotaxis [IDA]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of angiogenesis [IMP]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [TAS]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of phospholipase C activity [IMP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- protein autophosphorylation [IDA]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
- vascular endothelial growth factor receptor signaling pathway [IDA, IMP, TAS]
- vascular endothelial growth factor receptor-1 signaling pathway [IDA]
- vascular endothelial growth factor signaling pathway [IDA, IMP, TAS]
Gene Ontology Molecular Function- VEGF-A-activated receptor activity [IDA]
- VEGF-B-activated receptor activity [IDA]
- growth factor binding [IPI]
- placental growth factor-activated receptor activity [IDA]
- protein binding [IPI]
- transmembrane receptor protein tyrosine kinase activity [TAS]
- vascular endothelial growth factor-activated receptor activity [IDA, IMP]
- VEGF-A-activated receptor activity [IDA]
- VEGF-B-activated receptor activity [IDA]
- growth factor binding [IPI]
- placental growth factor-activated receptor activity [IDA]
- protein binding [IPI]
- transmembrane receptor protein tyrosine kinase activity [TAS]
- vascular endothelial growth factor-activated receptor activity [IDA, IMP]
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interaction of the Flt-1 tyrosine kinase receptor with the p85 subunit of phosphatidylinositol 3-kinase. Mapping of a novel site involved in binding.
We have examined the interactions of the p85 regulatory subunit of phosphatidylinositol 3-kinase with the endothelium-specific Flt-1 receptor tyrosine kinase using the yeast two-hybrid system. We find that both the amino- and carboxyl-terminal SH2 domains of p85 bind to Flt-1. We have performed site-directed mutagenesis on the carboxyl-terminal tail of the Flt-1 receptor in order to identify the site(s) that ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FLT1 PIK3R1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| PIK3R1 FLT1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| FLT1 PIK3R1 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | High | - | BioGRID | 3201847 |
Curated By
- BioGRID