BAIT
INPP5D
SHIP, SHIP-1, SHIP1, SIP-145, hp51CN, p150Ship
inositol polyphosphate-5-phosphatase, 145kDa
GO Process (9)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- T cell receptor signaling pathway [TAS]
- blood coagulation [TAS]
- inositol phosphate metabolic process [TAS]
- leukocyte migration [TAS]
- phosphate-containing compound metabolic process [TAS]
- phosphatidylinositol biosynthetic process [TAS]
- phospholipid metabolic process [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
FCGR2B
CD32, CD32B, FCG2, FCGR2, IGFR2, RP11-474I16.2
Fc fragment of IgG, low affinity IIb, receptor (CD32)
GO Process (3)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Fc gamma receptor type IIb induced recruitment of inositol and protein phosphatases to the signal transductory complex of human B-cell.
Co-clustering of Fc gamma RIIb and B-cell receptor (BCR) inhibits cell activation by interrupting BCR stimulated signal transduction. The immunoreceptor tyrosine-based inhibitory motif (ITIM) of Fc gamma RIIb becomes tyrosyl phosphorylated (P-ITIM) upon co-clustering with BCR then P-ITIM interacts with several signalling molecules, some of which negatively regulate the cell activation process. The molecules recruited by the P-ITIM of human ... [more]
Immunol. Lett. Jun. 01, 1997; 57(1-3);159-64 [Pubmed: 9232445]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| INPP5D FCGR2B | Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments. | Low | - | BioGRID | - |
Curated By
- BioGRID