ATM
Gene Ontology Biological Process
- DNA damage induced protein phosphorylation [IDA]
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [TAS]
- DNA repair [TAS]
- cell cycle arrest [IMP]
- cellular response to DNA damage stimulus [IMP]
- cellular response to gamma radiation [IDA]
- double-strand break repair [TAS]
- double-strand break repair via homologous recombination [TAS]
- histone mRNA catabolic process [IDA]
- mitotic spindle assembly checkpoint [IMP]
- negative regulation of B cell proliferation [IMP]
- peptidyl-serine phosphorylation [IDA]
- phosphatidylinositol-3-phosphate biosynthetic process [IMP]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [IMP]
- positive regulation of apoptotic process [IMP]
- pre-B cell allelic exclusion [ISS]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- reciprocal meiotic recombination [TAS]
- replicative senescence [IMP]
- response to ionizing radiation [IDA]
- signal transduction [TAS]
- signal transduction involved in mitotic G2 DNA damage checkpoint [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
STK11
Gene Ontology Biological Process
- activation of protein kinase activity [IDA]
- anoikis [IMP]
- cell cycle arrest [IDA, TAS]
- energy reserve metabolic process [TAS]
- establishment of cell polarity [ISS]
- glucose homeostasis [ISS]
- insulin receptor signaling pathway [TAS]
- intrinsic apoptotic signaling pathway by p53 class mediator [IDA]
- negative regulation of cell growth [ISS]
- negative regulation of cell proliferation [IMP]
- positive regulation of transforming growth factor beta receptor signaling pathway [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of cell growth [ISS]
- regulation of fatty acid biosynthetic process [TAS]
- response to ionizing radiation [ISS]
- small molecule metabolic process [TAS]
- vasculature development [ISS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM.
The ATM protein kinase regulates the response of the cell to DNA damage by associating with and then phosphorylating proteins involved in cell cycle checkpoints and DNA repair. Here, we report on deletion studies designed to identify protein domains required for ATM to phosphorylate target proteins and to control cell survival following exposure to ionizing radiation. Deletion studies demonstrated that ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID