BAIT
BRCA2
BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11, RP11-298P3.4
breast cancer 2, early onset
GO Process (10)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- DNA repair [TAS]
- centrosome duplication [IMP]
- cytokinesis [IDA]
- double-strand break repair [IMP, TAS]
- double-strand break repair via homologous recombination [IDA, TAS]
- histone H3 acetylation [IDA]
- histone H4 acetylation [IDA]
- negative regulation of mammary gland epithelial cell proliferation [IDA]
- nucleotide-excision repair [IMP]
- positive regulation of transcription, DNA-templated [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SHANK1
SPANK-1, SSTRIP, synamon
SH3 and multiple ankyrin repeat domains 1
GO Process (16)
GO Function (10)
GO Component (11)
Gene Ontology Biological Process
- adult behavior [IMP]
- associative learning [ISS]
- cytoskeletal anchoring at plasma membrane [NAS]
- dendritic spine morphogenesis [ISS]
- determination of affect [IMP]
- long-term memory [ISS]
- negative regulation of actin filament bundle assembly [ISS]
- neuromuscular process controlling balance [ISS]
- positive regulation of dendritic spine development [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- protein complex assembly [ISS]
- protein localization to synapse [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- social behavior [IMP]
- synapse maturation [ISS]
- vocalization behavior [IMP]
Gene Ontology Molecular Function- GKAP/Homer scaffold activity [ISS]
- SH3 domain binding [ISS]
- ankyrin repeat binding [ISS]
- identical protein binding [ISS]
- ionotropic glutamate receptor binding [ISS]
- protein C-terminus binding [ISS]
- protein binding [IPI]
- protein complex binding [ISS]
- scaffold protein binding [ISS]
- somatostatin receptor binding [ISS]
- GKAP/Homer scaffold activity [ISS]
- SH3 domain binding [ISS]
- ankyrin repeat binding [ISS]
- identical protein binding [ISS]
- ionotropic glutamate receptor binding [ISS]
- protein C-terminus binding [ISS]
- protein binding [IPI]
- protein complex binding [ISS]
- scaffold protein binding [ISS]
- somatostatin receptor binding [ISS]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [ISS]
- dendrite [NAS]
- dendritic spine [ISS]
- excitatory synapse [ISS]
- intracellular [NAS]
- ionotropic glutamate receptor complex [ISS]
- membrane [IDA]
- neuron projection [ISS]
- neuronal postsynaptic density [ISS]
- plasma membrane [ISS]
- postsynaptic membrane [ISS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein.
BRCA2 is responsible for familial breast and ovarian cancer and has been linked to DNA repair and centrosome duplication. Here we analyzed the mechanism by which the centrosomal localization signal (CLS) of BRCA2 interacts with cytoplasmic dynein 1 to localize BRCA2 to the centrosome. In vitro pull-down assays demonstrated that BRCA2 directly binds to the cytoplasmic dynein 1 light intermediate ... [more]
Cell Cycle Aug. 17, 2016; 15(16);2145-2156 [Pubmed: 27433848]
Throughput
- High Throughput
Curated By
- BioGRID