BAIT
ATG16L1
APG16L, ATG16A, ATG16L, IBD10, WDR30, hCG_1817841
autophagy related 16-like 1 (S. cerevisiae)
GO Process (3)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RUVBL2
ECP51, INO80J, REPTIN, RVB2, TIH2, TIP48, TIP49B, CGI-46
RuvB-like AAA ATPase 2
GO Process (14)
GO Function (9)
GO Component (10)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- DNA duplex unwinding [IDA, TAS]
- cellular response to UV [IMP]
- cellular response to estradiol stimulus [IMP]
- chromatin organization [TAS]
- chromatin remodeling [IMP]
- establishment of protein localization to chromatin [IMP]
- histone H2A acetylation [IDA]
- histone H4 acetylation [IDA]
- negative regulation of estrogen receptor binding [IMP]
- positive regulation of histone acetylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein folding [TAS]
- transcriptional activation by promoter-enhancer looping [IMP]
Gene Ontology Molecular Function- ATP-dependent DNA helicase activity [TAS]
- ATPase activity [IDA]
- DNA helicase activity [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- chromatin DNA binding [IDA]
- identical protein binding [IDA, IPI]
- protein binding [IPI]
- unfolded protein binding [TAS]
- ATP-dependent DNA helicase activity [TAS]
- ATPase activity [IDA]
- DNA helicase activity [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- chromatin DNA binding [IDA]
- identical protein binding [IDA, IPI]
- protein binding [IPI]
- unfolded protein binding [TAS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ATG5 is required for B cell polarization and presentation of particulate antigens.
The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to ... [more]
Autophagy Feb. 01, 2019; 15(2);280-294 [Pubmed: 30196744]
Throughput
- High Throughput
Curated By
- BioGRID