SIAH1
Gene Ontology Biological Process
- anatomical structure morphogenesis [TAS]
- apoptotic process [TAS]
- axon guidance [TAS]
- nervous system development [TAS]
- neuron apoptotic process [ISS]
- positive regulation of apoptotic process [IDA]
- positive regulation of intrinsic apoptotic signaling pathway [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISS]
- protein catabolic process [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISS]
- ubiquitin-dependent protein catabolic process [IDA]
Gene Ontology Molecular Function
PEG10
Gene Ontology Biological Process
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1.
Through a genome-wide cDNA microarray, we identified that the paternally expressed gene 10 (PEG10) was highly expressed in a great majority of hepatocellular carcinomas, although its expression was absent in normal liver cells. Exogenous expression of PEG10 conferred oncogenic activity and transfection of hepatoma cells with antisense S-oligonucleotides suppressing PEG10 resulted in their growth inhibition. Additional experiments revealed that PEG10 ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PEG10 SIAH1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - | |
SIAH1 PEG10 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID