SWE1
Gene Ontology Biological Process
- G2 cell size control checkpoint [IEP, IMP]
- G2/M transition of mitotic cell cycle [IDA, IMP, ISS]
- cytokinesis after mitosis checkpoint [IDA, IEP, IMP]
- negative regulation of spindle pole body separation [IGI, IMP]
- protein phosphorylation [IDA]
- re-entry into mitotic cell cycle [IGI]
- regulation of cell size [IMP]
- regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- regulation of meiosis [IEP, IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BEM1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
Sequential and distinct roles of the cadherin domain-containing protein Axl2p in cell polarization in yeast cell cycle.
Polarization of cell growth along a defined axis is essential for the generation of cell and tissue polarity. In the budding yeast Saccharomyces cerevisiae, Axl2p plays an essential role in polarity-axis determination, or more specifically, axial budding in MATa or alpha cells. Axl2p is a type I membrane glycoprotein containing four cadherin-like motifs in its extracellular domain. However, it is ... [more]
Throughput
- Low Throughput
Ontology Terms
- heat sensitivity (APO:0000147)
- bud morphology (APO:0000212)
- vegetative growth (APO:0000106)
Additional Notes
- Deletion of swe1 rescues a cdc42 mutant or a cdc42 axl2 double mutant. The cdc42 axl2 swe1 triple mutant shows normal growth.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SWE1 BEM1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2091 | BioGRID | 389397 | |
| BEM1 SWE1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2091 | BioGRID | 359160 | |
| SWE1 BEM1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -11.337 | BioGRID | 322242 | |
| BEM1 SWE1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.209 | BioGRID | 910593 | |
| BEM1 SWE1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID