CXCR3
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP]
- cell adhesion [TAS]
- cell surface receptor signaling pathway [IDA]
- cellular component movement [TAS]
- chemokine (C-C motif) ligand 11 production [IDA]
- chemokine-mediated signaling pathway [TAS]
- chemotaxis [TAS]
- negative regulation of angiogenesis [IDA]
- negative regulation of endothelial cell proliferation [IDA]
- negative regulation of execution phase of apoptosis [IDA]
- positive regulation of angiogenesis [IDA]
- positive regulation of cAMP metabolic process [IDA]
- positive regulation of cAMP-mediated signaling [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of chemotaxis [IDA]
- positive regulation of execution phase of apoptosis [IDA]
- positive regulation of release of sequestered calcium ion into cytosol [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PF4
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IBA]
- blood coagulation [TAS]
- chemokine-mediated signaling pathway [IBA]
- cytokine-mediated signaling pathway [IDA]
- immune response [IBA]
- inflammatory response [IBA]
- leukocyte chemotaxis [IDA]
- negative regulation of MHC class II biosynthetic process [IDA]
- negative regulation of angiogenesis [IDA]
- negative regulation of cytolysis [IDA]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- negative regulation of megakaryocyte differentiation [IDA]
- platelet activation [IDA, TAS]
- platelet degranulation [TAS]
- positive regulation of cAMP metabolic process [IDA]
- positive regulation of cAMP-mediated signaling [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of leukocyte chemotaxis [IBA]
- positive regulation of macrophage derived foam cell differentiation [IDA]
- positive regulation of macrophage differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor production [IDA]
- regulation of cell proliferation [IDA]
- response to lipopolysaccharide [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4.
The chemokines CXCL9/Mig, CXCL10/IP-10, and CXCL11/I-TAC regulate lymphocyte chemotaxis, mediate vascular pericyte proliferation, and act as angiostatic agents, thus inhibiting tumor growth. These multiple activities are apparently mediated by a unique G protein-coupled receptor, termed CXCR3. The chemokine CXCL4/PF4 shares several activities with CXCL9, CXCL10, and CXCL11, including a powerful angiostatic effect, but its specific receptor is still unknown. Here, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID