BAIT

RND3

ARHE, Rho8, RhoE, memB
Rho family GTPase 3
GO Process (3)
GO Function (2)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

CIT

CRIK, STK21
citron rho-interacting serine/threonine kinase
Cell Cycle - Mitotic Spindle Assembly Project
GO Process (4)
GO Function (3)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

RhoE binds to ROCK I and inhibits downstream signaling.

Riento K, Guasch RM, Garg R, Jin B, Ridley AJ

RhoE belongs to the Rho GTPase family, the members of which control actin cytoskeletal dynamics. RhoE induces stress fiber disassembly in a variety of cell types, whereas RhoA stimulates stress fiber assembly. The similarity of RhoE and RhoA sequences suggested that RhoE might compete with RhoA for interaction with its targets. Here, we show that RhoE binds ROCK I but ... [more]

Mol. Cell. Biol. Jun. 01, 2003; 23(12);4219-29 [Pubmed: 12773565]

Throughput

  • Low Throughput

Curated By

  • BioGRID