BAIT
HMGA2
BABL, HMGI-C, HMGIC, LIPO, STQTL9
high mobility group AT-hook 2
GO Process (42)
GO Function (19)
GO Component (6)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IDA]
- DNA damage response, detection of DNA damage [IDA]
- base-excision repair [IDA]
- chondrocyte differentiation [IDA]
- chondrocyte proliferation [IDA]
- chromatin organization [TAS]
- chromosome breakage [IDA]
- endodermal cell differentiation [IMP]
- epithelial to mesenchymal transition [IMP]
- fat cell differentiation [IMP]
- heterochromatin assembly [IDA]
- histone H2A-S139 phosphorylation [IDA]
- mesenchymal cell differentiation [IMP]
- mesodermal cell differentiation [IMP]
- mesodermal-endodermal cell signaling [IMP]
- mitotic G2 DNA damage checkpoint [IDA]
- multicellular organismal development [TAS]
- negative regulation by host of viral transcription [IDA]
- negative regulation of DNA binding [IDA]
- negative regulation of apoptotic process [IDA]
- negative regulation of double-strand break repair via nonhomologous end joining [IDA]
- negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- oncogene-induced cell senescence [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of cellular response to X-ray [IDA]
- positive regulation of cellular senescence [IMP]
- positive regulation of gene expression [IDA]
- positive regulation of response to DNA damage stimulus [IDA]
- positive regulation of stem cell proliferation [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription regulatory region DNA binding [IDA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- regulation of cell cycle process [IDA]
- regulation of cellular response to drug [IDA]
- regulation of stem cell maintenance [IMP, TAS]
- regulation of transcription, DNA-templated [IMP]
- response to virus [IEP]
- senescence-associated heterochromatin focus assembly [IDA]
- stem cell differentiation [IEP]
Gene Ontology Molecular Function- 5'-deoxyribose-5-phosphate lyase activity [IDA]
- AT DNA binding [IDA, IMP]
- C2H2 zinc finger domain binding [IMP]
- DNA binding [NAS]
- DNA binding, bending [IDA, IMP]
- DNA-(apurinic or apyrimidinic site) lyase activity [IDA]
- DNA-dependent protein kinase activity [IDA]
- MH1 domain binding [IDA]
- MH2 domain binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [IPI]
- cAMP response element binding [IDA]
- core promoter binding [IDA]
- nucleosomal DNA binding [IDA]
- protein binding [IPI]
- regulatory region DNA binding [IDA]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- 5'-deoxyribose-5-phosphate lyase activity [IDA]
- AT DNA binding [IDA, IMP]
- C2H2 zinc finger domain binding [IMP]
- DNA binding [NAS]
- DNA binding, bending [IDA, IMP]
- DNA-(apurinic or apyrimidinic site) lyase activity [IDA]
- DNA-dependent protein kinase activity [IDA]
- MH1 domain binding [IDA]
- MH2 domain binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [IPI]
- cAMP response element binding [IDA]
- core promoter binding [IDA]
- nucleosomal DNA binding [IDA]
- protein binding [IPI]
- regulatory region DNA binding [IDA]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
RELA
NFKB3, p65
v-rel avian reticuloendotheliosis viral oncogene homolog A
GO Process (43)
GO Function (20)
GO Component (5)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- T cell receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- cellular defense response [NAS]
- cellular response to hydrogen peroxide [IDA]
- cellular response to interleukin-1 [IDA]
- cellular response to interleukin-6 [IMP]
- cellular response to nicotine [IMP]
- cellular response to peptide hormone stimulus [IMP]
- cellular response to tumor necrosis factor [IDA]
- cytokine-mediated signaling pathway [IDA]
- defense response to virus [NAS]
- inflammatory response [IDA]
- innate immune response [TAS]
- membrane protein intracellular domain proteolysis [TAS]
- negative regulation of apoptotic process [IDA, TAS]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing 2 signaling pathway [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of NF-kappaB transcription factor activity [IDA, TAS]
- positive regulation of cell proliferation [IDA]
- positive regulation of miRNA metabolic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of type I interferon production [TAS]
- regulation of inflammatory response [ISS]
- response to UV-B [IDA]
- response to interleukin-1 [IGI]
- response to organic substance [IDA]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- NF-kappaB binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- activating transcription factor binding [IPI]
- chromatin binding [IDA]
- identical protein binding [IDA, IPI]
- phosphate ion binding [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- ubiquitin protein ligase binding [IPI]
- DNA binding [IDA]
- NF-kappaB binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- activating transcription factor binding [IPI]
- chromatin binding [IDA]
- identical protein binding [IDA, IPI]
- phosphate ion binding [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- ubiquitin protein ligase binding [IPI]
Homo sapiens
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Molecular dissection of the architectural transcription factor HMGA2.
HMGA2 protein belongs to the High Mobility Group A (HMGA) family of architectural transcription factors. These proteins establish a network of protein-protein and protein-DNA interactions resulting in the formation of enhanceosomes at promoters and enhancers regulating the expression of several genes. HMGA2 dysregulation, as a result of specific chromosomal rearrangements, has been identified in a variety of common benign mesenchymal ... [more]
Biochemistry Apr. 22, 2003; 42(15);4569-77 [Pubmed: 12693954]
Throughput
- Low Throughput
Curated By
- BioGRID