CTSB
Gene Ontology Biological Process
- cellular response to thyroid hormone stimulus [IEP]
- collagen catabolic process [IDA, TAS]
- epithelial cell differentiation [IEP]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- innate immune response [TAS]
- proteolysis [IDA]
- proteolysis involved in cellular protein catabolic process [IDA]
- regulation of apoptotic process [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CST3
Gene Ontology Biological Process
- defense response [IDA]
- extracellular fibril organization [IGI]
- negative regulation of blood vessel remodeling [IEP]
- negative regulation of collagen catabolic process [IEP]
- negative regulation of elastin catabolic process [IMP]
- negative regulation of endopeptidase activity [IDA]
- negative regulation of extracellular matrix disassembly [IC, IEP]
- negative regulation of peptidase activity [IDA]
- negative regulation of proteolysis [IDA]
- regulation of tissue remodeling [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis.
Chronic HIV infection leads to the development of cognitive impairments, designated as HIV-associated neurocognitive disorders (HAND). The secretion of soluble neurotoxic factors by HIV-infected macrophages plays a central role in the neuronal dysfunction and cell death associated with HAND. One potentially neurotoxic protein secreted by HIV-1 infected macrophages is cathepsin B. To explore the potential role of cathepsin B in ... [more]
Throughput
- Low Throughput
Additional Notes
- PLA
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CST3 CTSB | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9885 | BioGRID | 3053031 | |
| CTSB CST3 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID