TNIP2
Gene Ontology Biological Process
- CD40 signaling pathway [ISS]
- cellular response to lipopolysaccharide [ISS]
- interleukin-1-mediated signaling pathway [ISS]
- negative regulation of endothelial cell apoptotic process [IDA]
- positive regulation of B cell activation [ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of macrophage activation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein stabilization [ISS]
- toll-like receptor 2 signaling pathway [ISS]
- toll-like receptor 3 signaling pathway [ISS]
- toll-like receptor 9 signaling pathway [ISS]
Gene Ontology Molecular Function
SHARPIN
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.
Tumor Necrosis Factor (TNF) has a crucial role in inflammation, cell proliferation and cell death. Dysregulation of TNF receptor 1 (TNFR1)-induced Nuclear Factor-kappa B (NF-κB) signaling leads to chronic inflammation and is associated with several human inflammatory pathologies. Hence, TNF neutralization suppresses inflammation and attenuates inflammatory pathology. However, despite its beneficial effects, anti-TNF therapy suffers from efficacy issues and severe ... [more]
Throughput
- High Throughput
Additional Notes
- Virotrap
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SHARPIN TNIP2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2603708 |
Curated By
- BioGRID