BAIT
TGM2
G-ALPHA-h, GNAH, HEL-S-45, TG2, TGC, RP5-1054A22.2
transglutaminase 2
GO Process (5)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC25A5
2F1, AAC2, ANT2, T2, T3
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
GO Process (8)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- adenine transport [TAS]
- energy reserve metabolic process [TAS]
- negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [IMP]
- positive regulation of cell proliferation [IMP]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
- transport [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75.
Transglutaminase type 2 (TG2) is a multifunctional enzyme that plays a key role in mitochondria homeostasis under stressful cellular conditions. TG2 interactome analysis reveals an enzyme interaction with GRP75 (glucose-regulated protein 75). GRP75 localizes in mitochondria-associated membranes (MAMs) and acts as a bridging molecule between the two organelles by assembling the IP3R-GRP75-VDAC complex, which is involved in the transport of ... [more]
Cell Rep Dec. 26, 2017; 25(13);3573-3581.e4 [Pubmed: 30590033]
Throughput
- High Throughput
Curated By
- BioGRID