LRP1
Gene Ontology Biological Process
- aorta morphogenesis [ISS]
- apoptotic cell clearance [ISS]
- beta-amyloid clearance [TAS]
- lipoprotein transport [NAS]
- negative regulation of Wnt signaling pathway [ISS]
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway [ISS]
- negative regulation of smooth muscle cell migration [ISS]
- phototransduction, visible light [TAS]
- positive regulation of cholesterol efflux [ISS]
- positive regulation of lipid transport [ISS]
- regulation of actin cytoskeleton organization [ISS]
- regulation of cholesterol transport [ISS]
- regulation of phospholipase A2 activity [ISS]
- retinoid metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PRKCA
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- activation of adenylate cyclase activity [ISS]
- activation of phospholipase C activity [TAS]
- apoptotic signaling pathway [TAS]
- blood coagulation [TAS]
- desmosome assembly [IMP]
- energy reserve metabolic process [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- extracellular matrix organization [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gene expression [TAS]
- histone H3-T6 phosphorylation [IDA]
- innate immune response [TAS]
- mRNA metabolic process [TAS]
- negative regulation of adenylate cyclase activity [ISS]
- negative regulation of glial cell apoptotic process [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- phototransduction, visible light [TAS]
- platelet activation [TAS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of angiogenesis [IMP]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of cardiac muscle hypertrophy [ISS]
- positive regulation of cell adhesion [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of dense core granule biogenesis [ISS]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of lipopolysaccharide-mediated signaling pathway [IMP]
- positive regulation of macrophage differentiation [ISS]
- positive regulation of mitotic cell cycle [IMP]
- protein phosphorylation [IDA]
- regulation of insulin secretion [TAS]
- regulation of platelet aggregation [IDA]
- regulation of rhodopsin mediated signaling pathway [TAS]
- response to interleukin-1 [IMP]
- rhodopsin mediated signaling pathway [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Protein kinase C-alpha-mediated regulation of low-density lipoprotein receptor related protein and urokinase increases astrocytoma invasion.
Aggressive and infiltrative invasion is one of the hallmarks of glioblastoma. Low-density lipoprotein receptor-related protein (LRP) is expressed by glioblastoma, but the role of this receptor in astrocytic tumor invasion remains poorly understood. We show that activation of protein kinase C-alpha (PKC-alpha) phosphorylated and down-regulated LRP expression. Pretreatment of tumor cells with PKC inhibitors, phosphoinositide 3-kinase (PI3K) inhibitor, PKC-alpha small ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PRKCA LRP1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID