BAIT
MTDH
3D3, AEG-1, AEG1, LYRIC, LYRIC/3D3
metadherin
GO Process (8)
GO Function (6)
GO Component (10)
Gene Ontology Biological Process
- lipopolysaccharide-mediated signaling pathway [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of angiogenesis [IDA]
- positive regulation of autophagy [IDA]
- positive regulation of protein kinase B signaling [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LRP5
BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP7, OPPG, OPS, OPTA1, VBCH2
low density lipoprotein receptor-related protein 5
GO Process (29)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- Wnt signaling pathway [IDA]
- Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- adipose tissue development [IMP]
- anterior/posterior pattern specification [IBA]
- bone marrow development [IMP]
- bone morphogenesis [IMP]
- bone remodeling [IBA]
- branching involved in mammary gland duct morphogenesis [IBA]
- canonical Wnt signaling pathway [IDA, IMP]
- cholesterol homeostasis [IMP]
- embryonic camera-type eye morphogenesis [IBA]
- embryonic limb morphogenesis [IBA]
- embryonic retina morphogenesis in camera-type eye [IBA]
- gastrulation with mouth forming second [IBA]
- glucose catabolic process [IMP]
- negative regulation of osteoblast differentiation [IMP]
- negative regulation of protein serine/threonine kinase activity [IMP]
- osteoblast development [IBA]
- positive regulation of cell proliferation [IDA]
- positive regulation of fat cell differentiation [IMP]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of mitosis [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of blood pressure [IMP]
- regulation of canonical Wnt signaling pathway [IMP]
- regulation of insulin secretion involved in cellular response to glucose stimulus [IBA]
- retina morphogenesis in camera-type eye [IMP]
- retinal blood vessel morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Protein-RNA
An interaction is detected between and protein and an RNA in vitro.
Publication
Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.
Overexpression of metadherin (MTDH) has been documented in many solid tumors and is implicated in metastasis and chemoresistance. MTDH has been detected at the plasma membrane as well as in the cytoplasm and nucleus, and the function of MTDH in these locales remains under investigation. In the nucleus, MTDH acts as a transcription co-factor to induce expression of chemoresistance-associated genes. ... [more]
J. Biol. Chem. Feb. 10, 2012; 287(7);4485-91 [Pubmed: 22199357]
Throughput
- High Throughput
Additional Notes
- mRNAs only detected in the MTDH pulldown of BEZ-treated cells (PI3K/mTOR inhibitor)
Curated By
- BioGRID