BAIT
MTDH
3D3, AEG-1, AEG1, LYRIC, LYRIC/3D3
metadherin
GO Process (8)
GO Function (6)
GO Component (10)
Gene Ontology Biological Process
- lipopolysaccharide-mediated signaling pathway [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of angiogenesis [IDA]
- positive regulation of autophagy [IDA]
- positive regulation of protein kinase B signaling [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ECE1
ECE, RP3-329E20.1
endothelin converting enzyme 1
GO Process (13)
GO Function (4)
GO Component (12)
Gene Ontology Biological Process
- bradykinin catabolic process [IDA]
- calcitonin catabolic process [IDA]
- ear development [IMP]
- embryonic digit morphogenesis [IMP]
- endothelin maturation [IDA]
- heart development [IMP]
- hormone catabolic process [IDA]
- peptide hormone processing [IDA]
- positive regulation of receptor recycling [IMP]
- protein processing [IDA]
- regulation of systemic arterial blood pressure by endothelin [IC]
- regulation of vasoconstriction [IC]
- substance P catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Weibel-Palade body [IDA]
- early endosome [IDA]
- endosome [IDA]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [IDA]
- integral component of membrane [IDA]
- intrinsic component of endosome membrane [TAS]
- lysosomal membrane [IDA]
- membrane [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- vesicle [ISS]
Homo sapiens
Protein-RNA
An interaction is detected between and protein and an RNA in vitro.
Publication
Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.
Overexpression of metadherin (MTDH) has been documented in many solid tumors and is implicated in metastasis and chemoresistance. MTDH has been detected at the plasma membrane as well as in the cytoplasm and nucleus, and the function of MTDH in these locales remains under investigation. In the nucleus, MTDH acts as a transcription co-factor to induce expression of chemoresistance-associated genes. ... [more]
J. Biol. Chem. Feb. 10, 2012; 287(7);4485-91 [Pubmed: 22199357]
Throughput
- High Throughput
Additional Notes
- mRNAs only detected in the MTDH pulldown of BEZ-treated cells (PI3K/mTOR inhibitor)
Curated By
- BioGRID