BAIT
AURKA
AIK, ARK1, AURA, AURORA2, BTAK, PPP1R47, STK15, STK6, STK7, RP5-1167H4.6
aurora kinase A
GO Process (13)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- mitotic cell cycle [TAS]
- mitotic nuclear division [TAS]
- mitotic spindle organization [IBA]
- negative regulation of protein binding [IDA]
- positive regulation of mitosis [TAS]
- protein autophosphorylation [TAS]
- protein phosphorylation [IDA]
- regulation of centrosome cycle [TAS]
- regulation of cytokinesis [IBA]
- regulation of protein stability [IMP]
- spindle stabilization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- centrosome [IDA, TAS]
- chromosome passenger complex [IBA]
- condensed nuclear chromosome, centromeric region [IBA]
- cytosol [TAS]
- microtubule cytoskeleton [IDA]
- midbody [TAS]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- spindle [TAS]
- spindle microtubule [IDA]
- spindle midzone [IBA]
- spindle pole centrosome [IDA]
Homo sapiens
PREY
GADD45A
DDIT1, GADD45, RP5-975D15.1
growth arrest and DNA-damage-inducible, alpha
GO Process (11)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- DNA repair [TAS]
- activation of MAPKKK activity [IDA]
- apoptotic process [TAS]
- cellular response to ionizing radiation [IMP]
- cellular response to mechanical stimulus [IEP]
- positive regulation of JNK cascade [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of p38MAPK cascade [IDA]
- positive regulation of reactive oxygen species metabolic process [IMP]
- regulation of cyclin-dependent protein serine/threonine kinase activity [TAS]
- signal transduction in response to DNA damage [IMP]
Gene Ontology Molecular Function
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Gadd45a interacts with aurora-A and inhibits its kinase activity.
Centrosome stability is required for successful mitosis in mammalian cells. Amplification of the centrosome leads to chromosomal missegregation and generation of aneuploidy, which are closely associated with cell transformation and tumorigenesis (Doxsey, S. J. (2001) Nat. Cell Biol. 3, E105-E108; Hinchcliffe, E. H., and Sluder, G. (2001) Genes Dev. 15, 1167-1181; Pihan, G. A., Purohit, A., Wallace, J., Malhotra, R., ... [more]
J. Biol. Chem. Sep. 29, 2006; 281(39);28943-50 [Pubmed: 16772293]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GADD45A AURKA | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| GADD45A AURKA | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID