BAIT

RPS6KA1

HU-1, MAPKAPK1A, RSK, RSK1, p90Rsk, RP11-492M19.2
ribosomal protein S6 kinase, 90kDa, polypeptide 1
GO Process (26)
GO Function (4)
GO Component (4)

Gene Ontology Cellular Component

Homo sapiens
PREY

LTN1

C21orf10, C21orf98, RNF160, ZNF294, HSPC087
listerin E3 ubiquitin protein ligase 1
GO Process (0)
GO Function (1)
GO Component (0)

Gene Ontology Molecular Function

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

Proteomic analysis reveals a role for RSK in p120-catenin phosphorylation and melanoma cell-cell adhesion.

Meant A, Gao B, Lavoie G, Nourreddine S, Jung F, Aubert L, Tcherkezian J, Gingras AC, Roux PP

The RAS/mitogen-activated protein kinase (MAPK) signaling pathway regulates various biological functions, including cell survival, proliferation and migration. This pathway is frequently deregulated in cancer, including melanoma, which is the most aggressive form of skin cancer. RSK (p90 ribosomal S6 kinase) is a MAPK-activated protein kinase required for melanoma growth and proliferation, but relatively little is known about its function and ... [more]

Mol. Cell Proteomics Nov. 02, 2019; (); [Pubmed: 31678930]

Throughput

  • High Throughput

Additional Notes

  • BioID system
  • High confidence interaction (SAINT score greater than or equal to 0.85 and FDR less than or equal to 0.05)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
LTN1 RPS6KA1
Proximity Label-MS
Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

High-BioGRID
2563171

Curated By

  • BioGRID