BAIT

CASP8

ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5
caspase 8, apoptosis-related cysteine peptidase
GO Process (33)
GO Function (9)
GO Component (10)

Gene Ontology Biological Process

Homo sapiens
PREY

NOL3

ARC, FCM, MYP, NOP, NOP30
nucleolar protein 3 (apoptosis repressor with CARD domain)
GO Process (1)
GO Function (3)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

A? induces PUMA activation: a new mechanism for A?-mediated neuronal apoptosis.

Feng J, Meng C, Xing D

p53 upregulated modulator of apoptosis (PUMA) is a promising tumor therapy target because it elicits apoptosis and profound sensitivity to radiation and chemotherapy. However, inhibition of PUMA may be beneficial for curbing excessive apoptosis associated with neurodegenerative disorders. Alzheimer's disease (AD) is a representative neurodegenerative disease in which amyloid-? (A?) deposition causes neurotoxicity. The regulation of PUMA during A?-induced neuronal ... [more]

Neurobiol. Aging Feb. 01, 2015; 36(2);789-800 [Pubmed: 25457551]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
CASP8 NOL3
Affinity Capture-Western
Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Low-BioGRID
-
CASP8 NOL3
Phenotypic Suppression
Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
305097

Curated By

  • BioGRID