SASH1
Gene Ontology Biological Process
- positive regulation of JUN kinase activity [IMP]
- positive regulation of NIK/NF-kappaB signaling [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of lipopolysaccharide-mediated signaling pathway [IMP]
- positive regulation of p38MAPK cascade [IMP]
- protein polyubiquitination [IDA]
- regulation of protein K63-linked ubiquitination [IDA]
- regulation of protein autoubiquitination [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SPTBN1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.
The tumor-suppressor sterile ? motif- and Src-homology 3-domain containing 1 (SASH1) has clinical relevance in colorectal carcinoma and is associated specifically with metachronous metastasis. We sought to identify the molecular mechanisms linking decreased SASH1 expression with distant metastasis formation.SASH1-deficient, SASH1-depleted, or SASH1-overexpressing HCT116 colon cancer cells were generated by the Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated 9-method, RNA interference, and transient ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SASH1 SPTBN1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID