BAIT
DYNC1LI1
DNCLI1, LIC1
dynein, cytoplasmic 1, light intermediate chain 1
GO Process (1)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BUB1B
BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1
BUB1 mitotic checkpoint serine/threonine kinase B
GO Process (9)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- cell proliferation [TAS]
- mitotic cell cycle [TAS]
- mitotic cell cycle checkpoint [TAS]
- mitotic nuclear division [NAS]
- mitotic spindle assembly checkpoint [TAS]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- protein localization to kinetochore [IPI]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
The human cytoplasmic dynein interactome reveals novel activators of motility.
In human cells, cytoplasmic dynein-1 is essential for long-distance transport of many cargos, including organelles, RNAs, proteins, and viruses, towards microtubule minus ends. To understand how a single motor achieves cargo specificity, we identified the human dynein interactome by attaching a promiscuous biotin ligase ('BioID') to seven components of the dynein machinery, including a subunit of the essential cofactor dynactin. ... [more]
Elife Dec. 18, 2016; 6(); [Pubmed: 28718761]
Throughput
- High Throughput
Curated By
- BioGRID