BAIT
DRD2
D2DR, D2R
dopamine receptor D2
GO Process (54)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- adenohypophysis development [ISS]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [IDA]
- adult walking behavior [ISS]
- arachidonic acid secretion [IDA]
- associative learning [ISS]
- axonogenesis [ISS]
- behavioral response to cocaine [ISS]
- behavioral response to ethanol [ISS]
- branching morphogenesis of a nerve [ISS]
- cellular calcium ion homeostasis [IC]
- cerebral cortex GABAergic interneuron migration [ISS]
- circadian regulation of gene expression [ISS]
- dopamine metabolic process [IC]
- intracellular signal transduction [IDA]
- locomotory behavior [ISS]
- negative regulation of adenylate cyclase activity [IDA]
- negative regulation of blood pressure [ISS]
- negative regulation of cell migration [ISS]
- negative regulation of cell proliferation [ISS]
- negative regulation of dopamine receptor signaling pathway [ISS]
- negative regulation of protein kinase B signaling [ISS]
- negative regulation of protein secretion [IDA]
- negative regulation of synaptic transmission, glutamatergic [ISS]
- negative regulation of voltage-gated calcium channel activity [IDA]
- neurological system process involved in regulation of systemic arterial blood pressure [ISS]
- neuron-neuron synaptic transmission [ISS]
- peristalsis [ISS]
- phosphatidylinositol metabolic process [ISS]
- phospholipase C-activating dopamine receptor signaling pathway [IGI]
- positive regulation of cytokinesis [IMP]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [IDA]
- positive regulation of dopamine uptake involved in synaptic transmission [ISS]
- positive regulation of growth hormone secretion [ISS]
- positive regulation of neuroblast proliferation [ISS]
- prepulse inhibition [ISS]
- protein localization [ISS]
- regulation of cAMP metabolic process [IDA]
- regulation of dopamine uptake involved in synaptic transmission [IC]
- regulation of heart rate [ISS]
- regulation of long-term neuronal synaptic plasticity [ISS]
- regulation of potassium ion transport [ISS]
- regulation of sodium ion transport [ISS]
- regulation of synaptic transmission, GABAergic [ISS]
- release of sequestered calcium ion into cytosol [ISS]
- response to amphetamine [ISS]
- response to cocaine [ISS]
- response to drug [ISS]
- response to histamine [IDA]
- response to light stimulus [ISS]
- response to morphine [ISS]
- sensory perception of smell [ISS]
- synapse assembly [ISS]
- temperature homeostasis [ISS]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NEFM
NEF3, NF-M, NFM
neurofilament, medium polypeptide
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Neurofilament-M interacts with the D1 dopamine receptor to regulate cell surface expression and desensitization.
We used the yeast two-hybrid assay to identify novel proteins that interact with the D(1) dopamine receptor. The third cytoplasmic loop (residues 217-273) of the rat D(1) receptor was used as bait to identify clones encoding interacting proteins from a rat brain cDNA library. This identified two clones encoding the C terminus of rat neurofilament-M (NF-M) (residues 782-846). The NF-M ... [more]
J. Neurosci. Jul. 15, 2002; 22(14);5920-30 [Pubmed: 12122054]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID