Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

Fission yeast cells overproducing HSET/KIFC1 provides a useful tool for identification and evaluation of human kinesin-14 inhibitors.

Yukawa M, Yamauchi T, Kurisawa N, Ahmed S, Kimura KI, Toda T

Many human cancer cells contain more than two centrosomes, yet these cancer cells can form pseudo-bipolar spindles through the mechanism, called centrosome clustering, and survive, instead of committing lethal multipolar mitoses. Kinesin-14/HSET, a minus end-directed motor, plays a crucial role in centrosome clustering. Accordingly, HSET is deemed to be a promising chemotherapeutic target to selectively kill cancer cells. Recently, three ... [more]

Fungal Genet. Biol. Dec. 01, 2017; 116();33-41 [Pubmed: 29684553]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: vegetative growth (APO:0000106)

Additional Notes

  • Figure 1
  • Overexpression of cut7 rescues growth defect caused by HSET (human) overexpression in yeast

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
KIFC1 CUT7
Phenotypic Suppression
Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
2623443

Curated By

  • BioGRID