DRD2
Gene Ontology Biological Process
- adenohypophysis development [ISS]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [IDA]
- adult walking behavior [ISS]
- arachidonic acid secretion [IDA]
- associative learning [ISS]
- axonogenesis [ISS]
- behavioral response to cocaine [ISS]
- behavioral response to ethanol [ISS]
- branching morphogenesis of a nerve [ISS]
- cellular calcium ion homeostasis [IC]
- cerebral cortex GABAergic interneuron migration [ISS]
- circadian regulation of gene expression [ISS]
- dopamine metabolic process [IC]
- intracellular signal transduction [IDA]
- locomotory behavior [ISS]
- negative regulation of adenylate cyclase activity [IDA]
- negative regulation of blood pressure [ISS]
- negative regulation of cell migration [ISS]
- negative regulation of cell proliferation [ISS]
- negative regulation of dopamine receptor signaling pathway [ISS]
- negative regulation of protein kinase B signaling [ISS]
- negative regulation of protein secretion [IDA]
- negative regulation of synaptic transmission, glutamatergic [ISS]
- negative regulation of voltage-gated calcium channel activity [IDA]
- neurological system process involved in regulation of systemic arterial blood pressure [ISS]
- neuron-neuron synaptic transmission [ISS]
- peristalsis [ISS]
- phosphatidylinositol metabolic process [ISS]
- phospholipase C-activating dopamine receptor signaling pathway [IGI]
- positive regulation of cytokinesis [IMP]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [IDA]
- positive regulation of dopamine uptake involved in synaptic transmission [ISS]
- positive regulation of growth hormone secretion [ISS]
- positive regulation of neuroblast proliferation [ISS]
- prepulse inhibition [ISS]
- protein localization [ISS]
- regulation of cAMP metabolic process [IDA]
- regulation of dopamine uptake involved in synaptic transmission [IC]
- regulation of heart rate [ISS]
- regulation of long-term neuronal synaptic plasticity [ISS]
- regulation of potassium ion transport [ISS]
- regulation of sodium ion transport [ISS]
- regulation of synaptic transmission, GABAergic [ISS]
- release of sequestered calcium ion into cytosol [ISS]
- response to amphetamine [ISS]
- response to cocaine [ISS]
- response to drug [ISS]
- response to histamine [IDA]
- response to light stimulus [ISS]
- response to morphine [ISS]
- sensory perception of smell [ISS]
- synapse assembly [ISS]
- temperature homeostasis [ISS]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SSTR2
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [TAS]
- cell-cell signaling [TAS]
- cellular response to estradiol stimulus [IBA]
- cellular response to glucocorticoid stimulus [IBA]
- digestion [TAS]
- negative regulation of cell proliferation [TAS]
- neuropeptide signaling pathway [IBA]
- response to nutrient [TAS]
- somatostatin signaling pathway [IBA]
- synaptic transmission [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Heterooligomerization of human dopamine receptor 2 and somatostatin receptor 2 Co-immunoprecipitation and fluorescence resonance energy transfer analysis.
Somatostatin and dopamine receptors are well expressed and co-localized in several brain regions, suggesting the possibility of functional interactions. In the present study we used a combination of pharmacological, biochemical and photobleaching fluorescence resonance energy transfer (pbFRET) to determine the functional interactions between human somatostatin receptor 2 (hSSTR2) and human dopamine receptor 2 (hD2R) in both co-transfected CHO-K1 or HEK-293 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DRD2 SSTR2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| DRD2 SSTR2 | FRET FRET An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID