BAIT
GJB1
CMTX, CMTX1, CX32
gap junction protein, beta 1, 32kDa
GO Process (5)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
HNRNPH1
HNRPH, HNRPH1, hnRNPH
heterogeneous nuclear ribonucleoprotein H1 (H)
GO Process (5)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration.
A fundamental step in membrane protein biogenesis is their integration into the lipid bilayer with a defined orientation of each transmembrane segment. Despite this, it remains unclear how cells detect and handle failures in this process. Here we show that single point mutations in the membrane protein connexin 32 (Cx32), which cause Charcot-Marie-Tooth disease, can cause failures in membrane integration. ... [more]
Nat Commun Dec. 08, 2018; 10(1);672 [Pubmed: 30737405]
Throughput
- High Throughput
Additional Notes
- Source of GJB1 not clear
Curated By
- BioGRID