LCK
Gene Ontology Biological Process
- B cell receptor signaling pathway [IBA]
- Fc-epsilon receptor signaling pathway [TAS]
- T cell costimulation [TAS]
- T cell differentiation [IMP, ISS]
- T cell receptor signaling pathway [TAS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA, ISS]
- blood coagulation [TAS]
- cellular response to peptide hormone stimulus [IBA]
- cellular zinc ion homeostasis [IEP, ISS]
- dephosphorylation [IDA, ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- hemopoiesis [NAS]
- innate immune response [IBA, TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- phosphatidylinositol-mediated signaling [TAS]
- platelet activation [TAS]
- positive regulation of T cell activation [IDA, ISS]
- positive regulation of T cell receptor signaling pathway [NAS]
- positive regulation of intrinsic apoptotic signaling pathway [IMP, ISS]
- protein phosphorylation [IDA]
- regulation of cell proliferation [IBA]
- regulation of defense response to virus by virus [TAS]
- regulation of lymphocyte activation [NAS]
- release of sequestered calcium ion into cytosol [ISS]
- response to drug [IDA, ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
- viral process [TAS]
Gene Ontology Molecular Function- ATPase binding [IPI]
- CD4 receptor binding [IPI]
- CD8 receptor binding [IPI]
- SH2 domain binding [IPI, ISS]
- glycoprotein binding [IPI]
- identical protein binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphatidylinositol 3-kinase binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- protein serine/threonine phosphatase activity [IDA, ISS]
- protein tyrosine kinase activity [EXP, IDA, ISS, TAS]
- ATPase binding [IPI]
- CD4 receptor binding [IPI]
- CD8 receptor binding [IPI]
- SH2 domain binding [IPI, ISS]
- glycoprotein binding [IPI]
- identical protein binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphatidylinositol 3-kinase binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- protein serine/threonine phosphatase activity [IDA, ISS]
- protein tyrosine kinase activity [EXP, IDA, ISS, TAS]
Gene Ontology Cellular Component
MAPT
Gene Ontology Biological Process
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- generation of neurons [NAS]
- microtubule cytoskeleton organization [IDA]
- positive regulation of axon extension [IDA]
- positive regulation of microtubule polymerization [IDA]
- regulation of autophagy [IGI]
- regulation of microtubule polymerization [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Tau interacts with src-family non-receptor tyrosine kinases.
Tau and other microtubule-associated proteins promote the assembly and stabilization of neuronal microtubules. While each microtubule-associated protein has distinct properties, their in vivo roles remain largely unknown. Tau is important in neurite outgrowth and axonal development. Recently, we showed that the amino-terminal region of tau, which is not involved in microtubule interactions, is important in NGF induced neurite outgrowth in ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LCK MAPT | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 2624169 |
Curated By
- BioGRID