GATA4
Gene Ontology Biological Process
- atrial septum morphogenesis [IMP]
- atrial septum primum morphogenesis [ISS]
- atrial septum secundum morphogenesis [IMP]
- blood coagulation [TAS]
- cardiac right ventricle morphogenesis [ISS]
- cardiac ventricle morphogenesis [TAS]
- cell-cell signaling [ISS]
- embryonic foregut morphogenesis [ISS]
- embryonic heart tube anterior/posterior pattern specification [ISS]
- endocardial cushion development [IMP, ISS]
- endoderm development [TAS]
- heart looping [ISS]
- intestinal epithelial cell differentiation [IDA]
- male gonad development [IEP, IMP]
- positive regulation of angiogenesis [ISS]
- positive regulation of cardioblast differentiation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- positive regulation vascular endothelial growth factor production [ISS]
- regulation of transcription, DNA-templated [ISS]
- response to drug [IMP]
- transcription from RNA polymerase II promoter [ISS]
- ventricular septum development [ISS]
Gene Ontology Molecular Function- DNA binding [IDA, ISS]
- RNA polymerase II transcription factor binding transcription factor activity [IDA]
- activating transcription factor binding [ISS]
- co-SMAD binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA, ISS]
- RNA polymerase II transcription factor binding transcription factor activity [IDA]
- activating transcription factor binding [ISS]
- co-SMAD binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
HAND2
Gene Ontology Biological Process
- adult heart development [IEP]
- apoptotic process [ISS]
- cardiac neural crest cell development involved in outflow tract morphogenesis [ISS]
- heart development [NAS]
- heart looping [ISS]
- heart morphogenesis [ISS]
- in utero embryonic development [ISS]
- negative regulation of cardiac muscle cell apoptotic process [ISS]
- neural crest cell development [ISS]
- noradrenergic neuron differentiation [NAS]
- positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process [ISS]
- positive regulation of transcription regulatory region DNA binding [IDA]
- positive regulation of transcription, DNA-templated [ISS]
- regulation of secondary heart field cardioblast proliferation [ISS]
- regulation of transcription, DNA-templated [ISS]
- thymus development [ISS]
Gene Ontology Molecular Function- AT DNA binding [IDA]
- E-box binding [IDA, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [ISS]
- protein binding [IPI]
- protein homodimerization activity [ISS]
- transcription coactivator activity [ISS]
- transcription factor binding [ISS]
- transcription regulatory region DNA binding [ISS]
- AT DNA binding [IDA]
- E-box binding [IDA, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [ISS]
- protein binding [IPI]
- protein homodimerization activity [ISS]
- transcription coactivator activity [ISS]
- transcription factor binding [ISS]
- transcription regulatory region DNA binding [ISS]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism.
An intricate array of heterogeneous transcription factors participate in programming tissue-specific gene expression through combinatorial interactions that are unique to a given cell-type. The zinc finger-containing transcription factor GATA4, which is widely expressed in mesodermal and endodermal derived tissues, is thought to regulate cardiac myocyte-specific gene expression through combinatorial interactions with other semi-restricted transcription factors such as myocyte enhancer factor ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GATA4 HAND2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID