BAIT
APEX1
APE, APE1, APEN, APEX, APX, HAP1, REF1
APEX nuclease (multifunctional DNA repair enzyme) 1
GO Process (9)
GO Function (19)
GO Component (10)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IDA, TAS]
- DNA catabolic process, exonucleolytic [IBA]
- DNA demethylation [IDA]
- DNA repair [IDA, TAS]
- base-excision repair [IBA, TAS]
- negative regulation of nucleic acid-templated transcription [TAS]
- oxidation-reduction process [IDA]
- positive regulation of DNA repair [IDA]
- regulation of mRNA stability [IMP]
Gene Ontology Molecular Function- 3'-5' exonuclease activity [IDA, TAS]
- DNA binding [IDA]
- DNA-(apurinic or apyrimidinic site) lyase activity [IDA, TAS]
- RNA-DNA hybrid ribonuclease activity [TAS]
- chromatin DNA binding [IDA]
- damaged DNA binding [IDA]
- double-stranded DNA 3'-5' exodeoxyribonuclease activity [IBA]
- endodeoxyribonuclease activity [TAS]
- endonuclease activity [IDA]
- metal ion binding [IDA]
- oxidoreductase activity [IDA]
- phosphodiesterase I activity [TAS]
- phosphoric diester hydrolase activity [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- site-specific endodeoxyribonuclease activity, specific for altered base [IDA]
- transcription coactivator activity [IDA]
- transcription corepressor activity [TAS]
- uracil DNA N-glycosylase activity [TAS]
- 3'-5' exonuclease activity [IDA, TAS]
- DNA binding [IDA]
- DNA-(apurinic or apyrimidinic site) lyase activity [IDA, TAS]
- RNA-DNA hybrid ribonuclease activity [TAS]
- chromatin DNA binding [IDA]
- damaged DNA binding [IDA]
- double-stranded DNA 3'-5' exodeoxyribonuclease activity [IBA]
- endodeoxyribonuclease activity [TAS]
- endonuclease activity [IDA]
- metal ion binding [IDA]
- oxidoreductase activity [IDA]
- phosphodiesterase I activity [TAS]
- phosphoric diester hydrolase activity [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- site-specific endodeoxyribonuclease activity, specific for altered base [IDA]
- transcription coactivator activity [IDA]
- transcription corepressor activity [TAS]
- uracil DNA N-glycosylase activity [TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
VEGFA
MVCD1, VEGF, VPF, RP1-261G23.1
vascular endothelial growth factor A
GO Process (97)
GO Function (16)
GO Component (7)
Gene Ontology Biological Process
- VEGF-activated neuropilin signaling pathway [ISS]
- activation of protein kinase activity [IDA]
- angiogenesis [IDA]
- artery morphogenesis [ISS]
- basophil chemotaxis [IDA]
- blood coagulation [TAS]
- branching morphogenesis of an epithelial tube [ISS]
- camera-type eye morphogenesis [ISS]
- cardiac muscle fiber development [ISS]
- cardiac vascular smooth muscle cell development [ISS]
- cell maturation [ISS]
- cell migration involved in sprouting angiogenesis [IDA]
- cellular response to hypoxia [IDA, TAS]
- cellular response to vascular endothelial growth factor stimulus [IDA]
- commissural neuron axon guidance [ISS]
- coronary artery morphogenesis [ISS]
- coronary vein morphogenesis [ISS]
- dopaminergic neuron differentiation [ISS]
- endothelial cell chemotaxis [IDA]
- epithelial cell differentiation [ISS]
- eye photoreceptor cell development [ISS]
- growth [ISS]
- heart morphogenesis [ISS]
- in utero embryonic development [ISS]
- induction of positive chemotaxis [IDA, NAS]
- kidney development [ISS]
- lactation [ISS]
- lung development [ISS]
- lymph vessel morphogenesis [ISS]
- macrophage differentiation [IDA]
- mammary gland alveolus development [ISS]
- mesoderm development [ISS]
- monocyte differentiation [IDA]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- nervous system development [TAS]
- outflow tract morphogenesis [ISS]
- ovarian follicle development [ISS]
- patterning of blood vessels [ISS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive chemotaxis [IDA]
- positive regulation of CREB transcription factor activity [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of angiogenesis [IDA, IMP]
- positive regulation of axon extension involved in axon guidance [ISS]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of branching involved in ureteric bud morphogenesis [ISS]
- positive regulation of cell adhesion [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell migration involved in sprouting angiogenesis [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [IDA]
- positive regulation of cellular component movement [IDA]
- positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [IDA]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of endothelial cell proliferation [IDA, ISS]
- positive regulation of epithelial cell proliferation [ISS]
- positive regulation of focal adhesion assembly [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of histone deacetylase activity [IDA]
- positive regulation of leukocyte migration [TAS]
- positive regulation of mast cell chemotaxis [IDA]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of neuroblast proliferation [ISS]
- positive regulation of p38MAPK cascade [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-tyrosine autophosphorylation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of positive chemotaxis [IDA]
- positive regulation of protein autophosphorylation [IDA]
- positive regulation of protein complex assembly [IDA]
- positive regulation of protein kinase C signaling [IDA]
- positive regulation of protein kinase D signaling [IDA]
- positive regulation of protein localization to early endosome [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of receptor internalization [IDA]
- positive regulation of retinal ganglion cell axon guidance [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [IMP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- positive regulation of vascular permeability [IDA]
- post-embryonic camera-type eye development [ISS]
- primitive erythrocyte differentiation [ISS]
- regulation of cGMP metabolic process [IDA]
- regulation of cell shape [IDA]
- regulation of retinal ganglion cell axon guidance [ISS]
- regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- response to hypoxia [IDA]
- surfactant homeostasis [ISS]
- tube formation [IDA]
- vascular endothelial growth factor receptor signaling pathway [IDA, TAS]
- vascular endothelial growth factor signaling pathway [IDA]
- vasculogenesis [TAS]
Gene Ontology Molecular Function- chemoattractant activity [IDA]
- cytokine activity [IDA, ISS]
- extracellular matrix binding [IC]
- fibronectin binding [IDA]
- growth factor activity [IDA, ISS]
- heparin binding [IDA, IMP]
- identical protein binding [IPI]
- neuropilin binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [ISS]
- receptor agonist activity [IPI]
- vascular endothelial growth factor receptor 1 binding [IPI]
- vascular endothelial growth factor receptor 2 binding [IPI]
- vascular endothelial growth factor receptor binding [IPI]
- chemoattractant activity [IDA]
- cytokine activity [IDA, ISS]
- extracellular matrix binding [IC]
- fibronectin binding [IDA]
- growth factor activity [IDA, ISS]
- heparin binding [IDA, IMP]
- identical protein binding [IPI]
- neuropilin binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [ISS]
- receptor agonist activity [IPI]
- vascular endothelial growth factor receptor 1 binding [IPI]
- vascular endothelial growth factor receptor 2 binding [IPI]
- vascular endothelial growth factor receptor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.
Mammalian apurinic/apyrimidinic endonuclease 1 is a DNA repair enzyme involved in genome stability and expression of genes involved in oxidative stress responses, tumor progression and chemoresistance. However, the molecular mechanisms underlying the role of apurinic/apyrimidinic endonuclease 1 in these processes are still unclear. Recent findings point to a novel role of apurinic/apyrimidinic endonuclease 1 in RNA metabolism. Through the characterization ... [more]
Nat Commun Dec. 06, 2016; 8(1);797 [Pubmed: 28986522]
Throughput
- High Throughput
Curated By
- BioGRID