BAIT
CD74
DHLAG, HLADG, II, Ia-GAMMA
CD74 molecule, major histocompatibility complex, class II invariant chain
GO Process (22)
GO Function (10)
GO Component (18)
Gene Ontology Biological Process
- T cell selection [NAS]
- antigen processing and presentation of endogenous antigen [NAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- cell proliferation [IDA]
- immunoglobulin mediated immune response [ISS]
- intracellular protein transport [ISS]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- negative regulation of apoptotic process [IDA]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- negative regulation of peptide secretion [IDA]
- positive regulation of B cell proliferation [IMP]
- positive regulation of ERK1 and ERK2 cascade [IDA, IMP]
- positive regulation of chemokine (C-X-C motif) ligand 2 production [ISS]
- positive regulation of cytokine-mediated signaling pathway [IMP]
- positive regulation of fibroblast proliferation [IMP]
- positive regulation of macrophage cytokine production [ISS]
- positive regulation of neutrophil chemotaxis [ISS]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- prostaglandin biosynthetic process [IDA]
- protein complex assembly [ISS]
- regulation of macrophage activation [NAS]
- signal transduction [IDA]
Gene Ontology Molecular Function- MHC class II protein binding [ISS, NAS]
- MHC class II protein binding, via antigen binding groove [IDA]
- MHC class II protein complex binding [IDA]
- beta-amyloid binding [IPI]
- cytokine binding [IPI]
- cytokine receptor activity [IDA]
- identical protein binding [TAS]
- macrophage migration inhibitory factor binding [IPI]
- protein binding [IPI]
- protein binding involved in protein folding [IDA]
- MHC class II protein binding [ISS, NAS]
- MHC class II protein binding, via antigen binding groove [IDA]
- MHC class II protein complex binding [IDA]
- beta-amyloid binding [IPI]
- cytokine binding [IPI]
- cytokine receptor activity [IDA]
- identical protein binding [TAS]
- macrophage migration inhibitory factor binding [IPI]
- protein binding [IPI]
- protein binding involved in protein folding [IDA]
Gene Ontology Cellular Component
- ER to Golgi transport vesicle membrane [TAS]
- Golgi membrane [TAS]
- MHC class II protein complex [ISS]
- cell surface [IDA]
- clathrin-coated endocytic vesicle membrane [TAS]
- endocytic vesicle membrane [TAS]
- extracellular vesicular exosome [IDA]
- integral component of lumenal side of endoplasmic reticulum membrane [TAS]
- integral component of membrane [IDA]
- intracellular [TAS]
- lysosomal lumen [TAS]
- lysosomal membrane [TAS]
- macrophage migration inhibitory factor receptor complex [IDA]
- membrane [IDA]
- plasma membrane [TAS]
- trans-Golgi network membrane [TAS]
- transport vesicle membrane [TAS]
- vacuole [IDA]
Homo sapiens
PREY
HADHB
ECHB, MTPB, TP-BETA, MSTP029
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
GO Process (6)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and spread. We conducted a mass-spectrometry-based survey to understand the fundamental organization of the innate immune system and to explore the molecular functions of individual ISGs. We identified interactions between 104 ISGs and 1,401 cellular binding partners engaging in ... [more]
Nat. Immunol. Dec. 01, 2018; 20(4);493-502 [Pubmed: 30833792]
Throughput
- High Throughput
Curated By
- BioGRID