BAIT
MAPKAPK2
MAPKAP-K2, MK-2, MK2
mitogen-activated protein kinase-activated protein kinase 2
GO Process (38)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA stabilization [IDA]
- G2 DNA damage checkpoint [IMP]
- MAPK cascade [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- RNA metabolic process [TAS]
- Ras protein signal transduction [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [TAS]
- arachidonic acid metabolic process [TAS]
- cellular response to DNA damage stimulus [IMP]
- cellular response to vascular endothelial growth factor stimulus [IMP]
- gene expression [TAS]
- inflammatory response [ISS]
- innate immune response [TAS]
- leukotriene metabolic process [TAS]
- mRNA metabolic process [TAS]
- macropinocytosis [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [IDA]
- protein phosphorylation [TAS]
- regulation of interleukin-6 production [ISS]
- regulation of tumor necrosis factor production [IDA]
- response to cytokine [IDA]
- response to lipopolysaccharide [ISS]
- response to stress [IDA]
- small molecule metabolic process [TAS]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [ISS, TAS]
- vascular endothelial growth factor receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EGF
HOMG4, URG
epidermal growth factor
GO Process (29)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- DNA replication [TAS]
- ERK1 and ERK2 cascade [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- STAT protein import into nucleus [ISS]
- activation of transmembrane receptor protein tyrosine kinase activity [TAS]
- angiogenesis [IDA]
- blood coagulation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- negative regulation of secretion [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of DNA binding [ISS]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of catenin import into nucleus [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of epidermal growth factor-activated receptor activity [IDA, TAS]
- positive regulation of hyaluronan biosynthetic process [IDA]
- positive regulation of mitosis [IDA]
- positive regulation of peptidyl-threonine phosphorylation [IDA]
- positive regulation of phosphorylation [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of calcium ion import [IDA]
- regulation of protein localization to cell surface [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.
We have identified a novel mitogen- and stress-activated protein kinase (MSK1) that contains two protein kinase domains in a single polypeptide. MSK1 is activated in vitro by MAPK2/ERK2 or SAPK2/p38. Endogenous MSK1 is activated in 293 cells by either growth factor/phorbol ester stimulation, or by exposure to UV radiation, and oxidative and chemical stress. The activation of MSK1 by growth ... [more]
EMBO J. Aug. 03, 1998; 17(15);4426-41 [Pubmed: 9687510]
Throughput
- Low Throughput
Curated By
- BioGRID