KAT2B
Gene Ontology Biological Process
- N-terminal peptidyl-lysine acetylation [IDA]
- Notch signaling pathway [TAS]
- cell cycle arrest [TAS]
- cellular response to insulin stimulus [IDA]
- chromatin organization [TAS]
- chromatin remodeling [IDA, NAS]
- gene expression [TAS]
- histone H3 acetylation [IDA]
- internal peptidyl-lysine acetylation [IDA]
- negative regulation of cell proliferation [IDA]
- peptidyl-lysine acetylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein acetylation [TAS]
- regulation of protein ADP-ribosylation [IDA]
- transcription from RNA polymerase I promoter [TAS]
- transcription initiation from RNA polymerase I promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- acetyltransferase activity [IDA]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [ISS]
- histone acetyltransferase activity [IDA]
- histone deacetylase binding [IPI]
- lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [IDA, ISS]
- protein binding [IPI]
- protein complex binding [IDA]
- protein kinase binding [ISS]
- transcription coactivator activity [IDA]
- transcription cofactor activity [IPI]
- transcription factor binding [IPI]
- acetyltransferase activity [IDA]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [ISS]
- histone acetyltransferase activity [IDA]
- histone deacetylase binding [IPI]
- lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [IDA, ISS]
- protein binding [IPI]
- protein complex binding [IDA]
- protein kinase binding [ISS]
- transcription coactivator activity [IDA]
- transcription cofactor activity [IPI]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
NCOA1
Gene Ontology Biological Process
- androgen receptor signaling pathway [NAS]
- cellular lipid metabolic process [TAS]
- cellular response to hormone stimulus [IBA]
- intracellular receptor signaling pathway [IBA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, NAS]
- positive regulation of transcription from RNA polymerase II promoter by galactose [IDA]
- positive regulation of transcription, DNA-templated [IDA, NAS]
- small molecule metabolic process [TAS]
- transcription, DNA-templated [IDA]
Gene Ontology Molecular Function- RNA polymerase II transcription coactivator activity [NAS]
- androgen receptor binding [NAS]
- enzyme binding [IPI]
- ligand-dependent nuclear receptor binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- nuclear hormone receptor binding [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IDA, NAS]
- RNA polymerase II transcription coactivator activity [NAS]
- androgen receptor binding [NAS]
- enzyme binding [IPI]
- ligand-dependent nuclear receptor binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- nuclear hormone receptor binding [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IDA, NAS]
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Steroid receptor coactivator-1 is a histone acetyltransferase.
Steroid receptors and coactivator proteins are thought to stimulate gene expression by facilitating the assembly of basal transcription factors into a stable preinitiation complex. What is not clear, however, is how these transcription factors gain access to transcriptionally repressed chromatin to modulate the transactivation of specific gene networks in vivo. The available evidence indicates that acetylation of chromatin in vivo ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KAT2B NCOA1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| NCOA1 KAT2B | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| NCOA1 KAT2B | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| KAT2B NCOA1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID