CBX4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RB1
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [TAS]
- Ras protein signal transduction [IEP]
- androgen receptor signaling pathway [NAS]
- cell cycle arrest [TAS]
- cell cycle checkpoint [TAS]
- chromatin remodeling [TAS]
- maintenance of mitotic sister chromatid cohesion [IMP]
- mitotic cell cycle [TAS]
- mitotic cell cycle checkpoint [TAS]
- myoblast differentiation [IMP]
- negative regulation of G1/S transition of mitotic cell cycle [TAS]
- negative regulation of protein kinase activity [IPI]
- negative regulation of sequence-specific DNA binding transcription factor activity [TAS]
- negative regulation of transcription from RNA polymerase II promoter during mitosis [TAS]
- negative regulation of transcription, DNA-templated [IDA, TAS]
- positive regulation of mitotic metaphase/anaphase transition [IMP]
- positive regulation of transcription, DNA-templated [NAS]
- protein localization to chromosome, centromeric region [IMP]
- regulation of centromere complex assembly [TAS]
- regulation of cohesin localization to chromatin [IMP]
- regulation of lipid kinase activity [IDA]
- regulation of mitotic cell cycle [IMP]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [TAS]
- sister chromatid biorientation [IMP]
Gene Ontology Molecular Function- DNA binding [TAS]
- androgen receptor binding [NAS]
- core promoter binding [IDA]
- identical protein binding [IPI]
- kinase binding [IDA]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [NAS]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [IPI]
- DNA binding [TAS]
- androgen receptor binding [NAS]
- core promoter binding [IDA]
- identical protein binding [IPI]
- kinase binding [IDA]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [NAS]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Linking the Rb and polycomb pathways.
Polycomb group (PcG) proteins associate to form complexes that repress Hox genes, thereby imposing the patterning of Hox expression required for development. However, these proteins have a second Hox-independent role in regulating cell proliferation. Our results suggest that association between Rb and PcG proteins forms a repressor complex that blocks entry of cells into mitosis. Also, we provide evidence that ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RB1 CBX4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CBX4 RB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 2600789 |
Curated By
- BioGRID