BAIT
ETAA1
ETAA16
Ewing tumor-associated antigen 1
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
KIF2C
CT139, KNSL6, MCAK, RP11-269F19.1
kinesin family member 2C
GO Process (12)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- ATP catabolic process [IBA]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- blood coagulation [TAS]
- cell proliferation [TAS]
- establishment or maintenance of microtubule cytoskeleton polarity [IMP]
- metabolic process [IBA, TAS]
- microtubule depolymerization [IDA, IMP]
- microtubule-based movement [IBA, TAS]
- mitotic cell cycle [TAS]
- mitotic metaphase plate congression [IMP]
- mitotic nuclear division [TAS]
- regulation of chromosome segregation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability.
The ATR kinase is a master regulator of the cellular response to DNA replication stress. Activation of ATR relies on dual pathways involving the TopBP1 and ETAA1 proteins, both of which harbor ATR-activating domains (AADs). However, the exact contribution of the recently discovered ETAA1 pathway to ATR signaling in different contexts remains poorly understood. Here, using an unbiased CRISPR-Cas9-based genome-scale ... [more]
J. Cell Biol. Dec. 02, 2019; 218(12);3943-3953 [Pubmed: 31615875]
Throughput
- High Throughput
Additional Notes
- CRISPR GI screen
- Cell Line: HELA
- Experimental Setup: Negative Selection
- GIST: A-phenotypic negative genetic interaction
- Library: Geckov2
- Significance Threshold: p<0.01
Curated By
- BioGRID