DRD2
Gene Ontology Biological Process
- adenohypophysis development [ISS]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [IDA]
- adult walking behavior [ISS]
- arachidonic acid secretion [IDA]
- associative learning [ISS]
- axonogenesis [ISS]
- behavioral response to cocaine [ISS]
- behavioral response to ethanol [ISS]
- branching morphogenesis of a nerve [ISS]
- cellular calcium ion homeostasis [IC]
- cerebral cortex GABAergic interneuron migration [ISS]
- circadian regulation of gene expression [ISS]
- dopamine metabolic process [IC]
- intracellular signal transduction [IDA]
- locomotory behavior [ISS]
- negative regulation of adenylate cyclase activity [IDA]
- negative regulation of blood pressure [ISS]
- negative regulation of cell migration [ISS]
- negative regulation of cell proliferation [ISS]
- negative regulation of dopamine receptor signaling pathway [ISS]
- negative regulation of protein kinase B signaling [ISS]
- negative regulation of protein secretion [IDA]
- negative regulation of synaptic transmission, glutamatergic [ISS]
- negative regulation of voltage-gated calcium channel activity [IDA]
- neurological system process involved in regulation of systemic arterial blood pressure [ISS]
- neuron-neuron synaptic transmission [ISS]
- peristalsis [ISS]
- phosphatidylinositol metabolic process [ISS]
- phospholipase C-activating dopamine receptor signaling pathway [IGI]
- positive regulation of cytokinesis [IMP]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [IDA]
- positive regulation of dopamine uptake involved in synaptic transmission [ISS]
- positive regulation of growth hormone secretion [ISS]
- positive regulation of neuroblast proliferation [ISS]
- prepulse inhibition [ISS]
- protein localization [ISS]
- regulation of cAMP metabolic process [IDA]
- regulation of dopamine uptake involved in synaptic transmission [IC]
- regulation of heart rate [ISS]
- regulation of long-term neuronal synaptic plasticity [ISS]
- regulation of potassium ion transport [ISS]
- regulation of sodium ion transport [ISS]
- regulation of synaptic transmission, GABAergic [ISS]
- release of sequestered calcium ion into cytosol [ISS]
- response to amphetamine [ISS]
- response to cocaine [ISS]
- response to drug [ISS]
- response to histamine [IDA]
- response to light stimulus [ISS]
- response to morphine [ISS]
- sensory perception of smell [ISS]
- synapse assembly [ISS]
- temperature homeostasis [ISS]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TRPC1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interaction with dopamine D2 receptor enhances expression of transient receptor potential channel 1 at the cell surface.
Receptor signaling is mediated by direct protein interaction with various types of cytoskeletal, adapter, effector, and additional receptor molecules. In brain tissue and in cultured neurons, activation of dopamine D2 receptors (D2Rs) has been found to impact cellular calcium signaling. Using a yeast two-hybrid approach, we have uncovered a direct physical interaction between the D2R and the transient receptor potential ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TRPC1 DRD2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| DRD2 TRPC1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID