BAIT
TSC1
LAM, TSC
tuberous sclerosis 1
GO Process (17)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
- activation of Rho GTPase activity [IDA]
- cell cycle arrest [TAS]
- cell-matrix adhesion [IMP]
- insulin receptor signaling pathway [TAS]
- negative regulation of TOR signaling [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of translation [IMP]
- positive regulation of focal adhesion assembly [IDA]
- protein stabilization [IDA]
- rRNA export from nucleus [IMP]
- regulation of cell cycle [IBA]
- regulation of cell-matrix adhesion [IMP]
- regulation of phosphoprotein phosphatase activity [IMP]
- regulation of stress fiber assembly [IDA]
- regulation of translation [IDA]
- response to insulin [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CDKN2B
CDK4I, INK4B, MTS2, P15, TP15, p15INK4b, RP11-149I2.1
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
GO Process (18)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [IMP]
- cell cycle arrest [IMP]
- cellular response to extracellular stimulus [IMP]
- cellular response to nutrient [IMP]
- gene expression [TAS]
- megakaryocyte differentiation [IEP]
- mitotic cell cycle [TAS]
- mitotic cell cycle checkpoint [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of phosphorylation [IDA]
- negative regulation of protein serine/threonine kinase activity [IDA, NAS]
- positive regulation of transcription from RNA polymerase II promoter [TAS]
- positive regulation of transforming growth factor beta receptor signaling pathway [IMP]
- regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies.
As genomics advances reveal the cancer gene landscape, a daunting task is to understand how these genes contribute to dysregulated oncogenic pathways. Integration of cancer genes into networks offers opportunities to reveal protein-protein interactions (PPIs) with functional and therapeutic significance. Here, we report the generation of a cancer-focused PPI network, termed OncoPPi, and identification of >260 cancer-associated PPIs not in ... [more]
Nat Commun Feb. 16, 2017; 8();14356 [Pubmed: 28205554]
Throughput
- High Throughput
Additional Notes
- Time-resolved fluorescence energy transfer (TR-FRET)
Curated By
- BioGRID