BAIT
TSC1
LAM, TSC
tuberous sclerosis 1
GO Process (17)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
- activation of Rho GTPase activity [IDA]
- cell cycle arrest [TAS]
- cell-matrix adhesion [IMP]
- insulin receptor signaling pathway [TAS]
- negative regulation of TOR signaling [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of translation [IMP]
- positive regulation of focal adhesion assembly [IDA]
- protein stabilization [IDA]
- rRNA export from nucleus [IMP]
- regulation of cell cycle [IBA]
- regulation of cell-matrix adhesion [IMP]
- regulation of phosphoprotein phosphatase activity [IMP]
- regulation of stress fiber assembly [IDA]
- regulation of translation [IDA]
- response to insulin [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FGFR4
CD334, JTK2, TKF
fibroblast growth factor receptor 4
GO Process (21)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- cell migration [IMP]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, IPI, TAS]
- glucose homeostasis [ISS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphate ion homeostasis [ISS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of DNA biosynthetic process [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of cell proliferation [IDA, IGI]
- positive regulation of metalloenzyme activity [IMP]
- positive regulation of proteolysis [IMP]
- protein autophosphorylation [IDA]
- regulation of bile acid biosynthetic process [IMP]
- regulation of cholesterol homeostasis [ISS]
- regulation of extracellular matrix disassembly [IMP]
- regulation of lipid metabolic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies.
As genomics advances reveal the cancer gene landscape, a daunting task is to understand how these genes contribute to dysregulated oncogenic pathways. Integration of cancer genes into networks offers opportunities to reveal protein-protein interactions (PPIs) with functional and therapeutic significance. Here, we report the generation of a cancer-focused PPI network, termed OncoPPi, and identification of >260 cancer-associated PPIs not in ... [more]
Nat Commun Feb. 16, 2017; 8();14356 [Pubmed: 28205554]
Throughput
- High Throughput
Additional Notes
- Time-resolved fluorescence energy transfer (TR-FRET)
Curated By
- BioGRID