BAIT
HSPA8
HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71
heat shock 70kDa protein 8
GO Process (14)
GO Function (11)
GO Component (13)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- RNA metabolic process [TAS]
- axon guidance [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- membrane organization [TAS]
- negative regulation of fibril organization [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurotransmitter secretion [TAS]
- post-Golgi vesicle-mediated transport [TAS]
- protein folding [NAS]
- protein refolding [IDA]
- response to unfolded protein [NAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function- ATP binding [IDA]
- ATPase activity [IDA]
- ATPase activity, coupled [NAS]
- G-protein coupled receptor binding [IPI]
- MHC class II protein complex binding [IDA]
- enzyme binding [IPI]
- heat shock protein binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- ATPase activity, coupled [NAS]
- G-protein coupled receptor binding [IPI]
- MHC class II protein complex binding [IDA]
- enzyme binding [IPI]
- heat shock protein binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [IDA]
Gene Ontology Cellular Component
- Prp19 complex [IDA]
- blood microparticle [IDA]
- clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [TAS]
- cytosol [IDA, TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- intracellular [NAS]
- membrane [IDA]
- nucleus [IDA]
- plasma membrane [TAS]
- ribonucleoprotein complex [IDA]
- ubiquitin ligase complex [IDA]
Homo sapiens
PREY
INS
IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10
insulin
GO Process (60)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- MAPK cascade [IDA]
- activation of protein kinase B activity [IDA]
- acute-phase response [IDA]
- alpha-beta T cell activation [IDA]
- cell-cell signaling [IC]
- cellular protein metabolic process [TAS]
- endocrine pancreas development [TAS]
- energy reserve metabolic process [TAS]
- fatty acid homeostasis [IMP]
- glucose homeostasis [IMP]
- glucose transport [IDA]
- insulin receptor signaling pathway [TAS]
- negative regulation of NAD(P)H oxidase activity [IDA]
- negative regulation of acute inflammatory response [IDA]
- negative regulation of fatty acid metabolic process [IMP]
- negative regulation of feeding behavior [IDA]
- negative regulation of gluconeogenesis [NAS]
- negative regulation of glycogen catabolic process [IMP]
- negative regulation of lipid catabolic process [IMP, NAS]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [NAS]
- negative regulation of protein catabolic process [IDA]
- negative regulation of protein oligomerization [IDA]
- negative regulation of protein secretion [IDA]
- negative regulation of proteolysis [IMP]
- negative regulation of respiratory burst involved in inflammatory response [IDA]
- negative regulation of vasodilation [NAS]
- positive regulation of DNA replication [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of brown fat cell differentiation [TAS]
- positive regulation of cell differentiation [NAS]
- positive regulation of cell growth [NAS]
- positive regulation of cell migration [ISS]
- positive regulation of cell proliferation [IDA]
- positive regulation of cellular protein metabolic process [IMP]
- positive regulation of cytokine secretion [IDA]
- positive regulation of glucose import [IDA]
- positive regulation of glycogen biosynthetic process [IDA]
- positive regulation of glycolytic process [IDA, IMP]
- positive regulation of insulin receptor signaling pathway [IDA]
- positive regulation of lipid biosynthetic process [NAS]
- positive regulation of mitosis [IDA]
- positive regulation of nitric oxide biosynthetic process [NAS]
- positive regulation of nitric-oxide synthase activity [NAS]
- positive regulation of peptide hormone secretion [TAS]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein autophosphorylation [ISS]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of respiratory burst [IDA]
- positive regulation of vasodilation [NAS]
- regulation of cellular amino acid metabolic process [IMP]
- regulation of insulin secretion [TAS]
- regulation of protein localization [IDA]
- regulation of protein secretion [IDA]
- regulation of transcription, DNA-templated [NAS]
- regulation of transmembrane transporter activity [IDA]
- small molecule metabolic process [TAS]
- wound healing [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
The disorderly conduct of Hsc70 and its interaction with the Alzheimer's-related Tau protein.
Hsp70 chaperones bind to various protein substrates for folding, trafficking, and degradation. Considerable structural information is available about how prokaryotic Hsp70 (DnaK) binds substrates, but less is known about mammalian Hsp70s, of which there are 13 isoforms encoded in the human genome. Here, we report the interaction between the human Hsp70 isoform heat shock cognate 71-kDa protein (Hsc70 or HSPA8) ... [more]
J. Biol. Chem. Dec. 06, 2017; 293(27);10796-10809 [Pubmed: 29764935]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| INS HSPA8 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID