A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

DSS1 interacts with and stimulates RAD52 to promote the repair of DSBs.

Stefanovie B, Hengel SR, Mlcouskova J, Prochazkova J, Spirek M, Nikulenkov F, Nemecek D, Koch BG, Bain FE, Yu L, Spies M, Krejci L

The proper repair of deleterious DNA lesions such as double strand breaks prevents genomic instability and carcinogenesis. In yeast, the Rad52 protein mediates DSB repair via homologous recombination. In mammalian cells, despite the presence of the RAD52 protein, the tumour suppressor protein BRCA2 acts as the predominant mediator during homologous recombination. For decades, it has been believed that the RAD52 ... [more]

Nucleic Acids Res. Dec. 24, 2019; 48(2);694-708 [Pubmed: 31799622]

Throughput

Low Throughput

Ontology Terms

phenotype: chromosome/plasmid maintenance (APO:0000143)

Additional Notes

Figure 1C
break induced repair

Curated By

BioGRID

Interaction Summary

RAD52

Gene Ontology Biological Process

Gene Ontology Molecular Function

identical protein binding [IPI]protein binding [IPI]

Gene Ontology Cellular Component

BRCA2

Gene Ontology Biological Process

Gene Ontology Molecular Function

H3 histone acetyltransferase activity [IDA]H4 histone acetyltransferase activity [IDA]gamma-tubulin binding [IPI]histone acetyltransferase activity [IDA]protease binding [IPI]protein binding [IPI]single-stranded DNA binding [IDA]