BAIT
PTEN
2310035O07Rik, A130070J02Rik, AI463227, B430203M17Rik, MMAC1, TEP1
phosphatase and tensin homolog
GO Process (72)
GO Function (13)
GO Component (13)
Gene Ontology Biological Process
- activation of mitotic anaphase-promoting complex activity [IMP, ISO]
- angiogenesis [IMP]
- brain morphogenesis [IMP]
- canonical Wnt signaling pathway [ISO]
- cardiac muscle tissue development [IMP]
- cell migration [IMP]
- central nervous system development [IMP]
- central nervous system myelin maintenance [IMP]
- central nervous system neuron axonogenesis [IMP]
- dendritic spine morphogenesis [IMP]
- dentate gyrus development [IMP]
- dephosphorylation [IDA]
- endothelial cell migration [IMP]
- forebrain morphogenesis [IMP]
- heart development [IMP]
- inositol phosphate dephosphorylation [ISO]
- learning or memory [IMP]
- locomotor rhythm [IMP]
- locomotory behavior [IMP]
- long term synaptic depression [ISO]
- long-term synaptic potentiation [IMP]
- male mating behavior [IMP]
- maternal behavior [IMP]
- memory [ISO]
- multicellular organismal response to stress [IMP]
- negative regulation of G1/S transition of mitotic cell cycle [ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of axonogenesis [IMP]
- negative regulation of cell aging [IMP]
- negative regulation of cell migration [ISO]
- negative regulation of cell proliferation [IGI, IMP, ISO]
- negative regulation of cell size [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [ISO]
- negative regulation of dendritic spine morphogenesis [IMP]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of excitatory postsynaptic membrane potential [IMP]
- negative regulation of focal adhesion assembly [ISO]
- negative regulation of myelination [IMP]
- negative regulation of organ growth [IMP]
- negative regulation of phagocytosis [ISO]
- negative regulation of protein kinase B signaling [IMP, ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of ribosome biogenesis [IMP]
- negative regulation of synaptic vesicle clustering [IMP]
- neuron projection development [ISO]
- neuron-neuron synaptic transmission [IMP]
- peptidyl-tyrosine dephosphorylation [ISO]
- phosphatidylinositol dephosphorylation [ISO]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of apoptotic signaling pathway [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of excitatory postsynaptic membrane potential [IMP]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- postsynaptic density assembly [IMP]
- prepulse inhibition [IMP]
- presynaptic membrane assembly [IMP]
- prostate gland growth [IMP]
- protein dephosphorylation [ISO]
- protein kinase B signaling [IMP]
- protein stabilization [ISO]
- regulation of B cell apoptotic process [IMP]
- regulation of cell cycle [IGI]
- regulation of cellular component size [IMP]
- regulation of myeloid cell apoptotic process [IMP]
- regulation of neuron projection development [IMP]
- regulation of protein stability [ISO]
- rhythmic synaptic transmission [IMP]
- social behavior [IMP]
- synapse assembly [IMP]
- synapse maturation [IMP]
Gene Ontology Molecular Function- PDZ domain binding [ISO]
- anaphase-promoting complex binding [ISO]
- enzyme binding [ISO]
- inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [ISO]
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [IDA, ISO]
- phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [ISO]
- phosphatidylinositol-3-phosphatase activity [ISO]
- phosphoprotein phosphatase activity [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine phosphatase activity [ISO]
- protein tyrosine phosphatase activity [ISO]
- PDZ domain binding [ISO]
- anaphase-promoting complex binding [ISO]
- enzyme binding [ISO]
- inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [ISO]
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [IDA, ISO]
- phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [ISO]
- phosphatidylinositol-3-phosphatase activity [ISO]
- phosphoprotein phosphatase activity [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine phosphatase activity [ISO]
- protein tyrosine phosphatase activity [ISO]
Gene Ontology Cellular Component
- Schmidt-Lanterman incisure [IDA]
- cell projection [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic side of plasma membrane [ISO]
- dendritic spine [ISO]
- intracellular [IMP]
- mitochondrion [ISO]
- myelin sheath adaxonal region [IDA]
- neuron projection [IDA, ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- plasma membrane [ISO]
- postsynaptic membrane [ISO]
Mus musculus
PREY
DLG1
B130052P05Rik, Dlgh1, E-dlg/SAP97, SAP-97, SAP97, mKIAA4187
discs, large homolog 1 (Drosophila)
GO Process (40)
GO Function (13)
GO Component (32)
Gene Ontology Biological Process
- T cell activation [IMP]
- T cell cytokine production [IMP]
- actin filament organization [ISO]
- activation of protein kinase activity [IMP]
- amyloid precursor protein metabolic process [IGI]
- branching involved in ureteric bud morphogenesis [IMP]
- cortical actin cytoskeleton organization [ISO]
- embryonic skeletal system morphogenesis [IMP]
- endothelial cell proliferation [ISO]
- establishment or maintenance of epithelial cell apical/basal polarity [IBA]
- hard palate development [IMP]
- immunological synapse formation [IMP]
- lens development in camera-type eye [IMP]
- membrane raft organization [IMP]
- negative regulation of T cell proliferation [IMP]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of mitotic cell cycle [ISO]
- negative regulation of protein kinase B signaling [IMP]
- nucleotide phosphorylation [IBA]
- peristalsis [IMP]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of developmental growth [TAS]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of multicellular organism growth [TAS]
- positive regulation of potassium ion transport [ISO]
- protein localization [IGI, IMP]
- protein localization to plasma membrane [ISO]
- receptor clustering [IBA]
- receptor localization to synapse [IBA]
- regulation of membrane potential [IGI, ISO]
- regulation of myelination [IMP]
- regulation of protein localization [ISO]
- reproductive structure development [IMP]
- single organismal cell-cell adhesion [ISO]
- smooth muscle tissue development [IMP]
- synaptic transmission [IBA]
- tight junction assembly [ISO]
- tissue morphogenesis [IMP]
- ureteric bud development [IMP]
Gene Ontology Molecular Function- L27 domain binding [ISO]
- PDZ domain binding [ISO]
- guanylate kinase activity [IBA]
- ion channel binding [ISO]
- ionotropic glutamate receptor binding [IBA, ISO]
- kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphatase binding [ISO]
- potassium channel regulator activity [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex scaffold [IMP]
- protein kinase binding [ISO]
- L27 domain binding [ISO]
- PDZ domain binding [ISO]
- guanylate kinase activity [IBA]
- ion channel binding [ISO]
- ionotropic glutamate receptor binding [IBA, ISO]
- kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphatase binding [ISO]
- potassium channel regulator activity [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex scaffold [IMP]
- protein kinase binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- MPP7-DLG1-LIN7 complex [ISO]
- T-tubule [ISO]
- basal lamina [IDA]
- basal plasma membrane [ISO]
- basolateral plasma membrane [IDA, ISO, TAS]
- cell junction [IDA, ISO]
- cell projection membrane [IDA]
- cell-cell adherens junction [TAS]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- cytoplasmic side of plasma membrane [ISO]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- immunological synapse [IDA]
- ionotropic glutamate receptor complex [IBA]
- lateral loop [IDA]
- lateral plasma membrane [IDA]
- membrane raft [IDA]
- microtubule [ISO]
- myelin sheath abaxonal region [IDA]
- neuromuscular junction [IDA]
- neuron projection [ISO]
- node of Ranvier [IDA]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA]
- presynaptic membrane [ISO]
- synapse [IDA]
- tight junction [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.719 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID