BAIT
PTEN
2310035O07Rik, A130070J02Rik, AI463227, B430203M17Rik, MMAC1, TEP1
phosphatase and tensin homolog
GO Process (72)
GO Function (13)
GO Component (13)
Gene Ontology Biological Process
- activation of mitotic anaphase-promoting complex activity [IMP, ISO]
- angiogenesis [IMP]
- brain morphogenesis [IMP]
- canonical Wnt signaling pathway [ISO]
- cardiac muscle tissue development [IMP]
- cell migration [IMP]
- central nervous system development [IMP]
- central nervous system myelin maintenance [IMP]
- central nervous system neuron axonogenesis [IMP]
- dendritic spine morphogenesis [IMP]
- dentate gyrus development [IMP]
- dephosphorylation [IDA]
- endothelial cell migration [IMP]
- forebrain morphogenesis [IMP]
- heart development [IMP]
- inositol phosphate dephosphorylation [ISO]
- learning or memory [IMP]
- locomotor rhythm [IMP]
- locomotory behavior [IMP]
- long term synaptic depression [ISO]
- long-term synaptic potentiation [IMP]
- male mating behavior [IMP]
- maternal behavior [IMP]
- memory [ISO]
- multicellular organismal response to stress [IMP]
- negative regulation of G1/S transition of mitotic cell cycle [ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of axonogenesis [IMP]
- negative regulation of cell aging [IMP]
- negative regulation of cell migration [ISO]
- negative regulation of cell proliferation [IGI, IMP, ISO]
- negative regulation of cell size [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [ISO]
- negative regulation of dendritic spine morphogenesis [IMP]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of excitatory postsynaptic membrane potential [IMP]
- negative regulation of focal adhesion assembly [ISO]
- negative regulation of myelination [IMP]
- negative regulation of organ growth [IMP]
- negative regulation of phagocytosis [ISO]
- negative regulation of protein kinase B signaling [IMP, ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of ribosome biogenesis [IMP]
- negative regulation of synaptic vesicle clustering [IMP]
- neuron projection development [ISO]
- neuron-neuron synaptic transmission [IMP]
- peptidyl-tyrosine dephosphorylation [ISO]
- phosphatidylinositol dephosphorylation [ISO]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of apoptotic signaling pathway [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of excitatory postsynaptic membrane potential [IMP]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- postsynaptic density assembly [IMP]
- prepulse inhibition [IMP]
- presynaptic membrane assembly [IMP]
- prostate gland growth [IMP]
- protein dephosphorylation [ISO]
- protein kinase B signaling [IMP]
- protein stabilization [ISO]
- regulation of B cell apoptotic process [IMP]
- regulation of cell cycle [IGI]
- regulation of cellular component size [IMP]
- regulation of myeloid cell apoptotic process [IMP]
- regulation of neuron projection development [IMP]
- regulation of protein stability [ISO]
- rhythmic synaptic transmission [IMP]
- social behavior [IMP]
- synapse assembly [IMP]
- synapse maturation [IMP]
Gene Ontology Molecular Function- PDZ domain binding [ISO]
- anaphase-promoting complex binding [ISO]
- enzyme binding [ISO]
- inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [ISO]
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [IDA, ISO]
- phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [ISO]
- phosphatidylinositol-3-phosphatase activity [ISO]
- phosphoprotein phosphatase activity [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine phosphatase activity [ISO]
- protein tyrosine phosphatase activity [ISO]
- PDZ domain binding [ISO]
- anaphase-promoting complex binding [ISO]
- enzyme binding [ISO]
- inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [ISO]
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [IDA, ISO]
- phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [ISO]
- phosphatidylinositol-3-phosphatase activity [ISO]
- phosphoprotein phosphatase activity [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine phosphatase activity [ISO]
- protein tyrosine phosphatase activity [ISO]
Gene Ontology Cellular Component
- Schmidt-Lanterman incisure [IDA]
- cell projection [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic side of plasma membrane [ISO]
- dendritic spine [ISO]
- intracellular [IMP]
- mitochondrion [ISO]
- myelin sheath adaxonal region [IDA]
- neuron projection [IDA, ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- plasma membrane [ISO]
- postsynaptic membrane [ISO]
Mus musculus
PREY
PTK2B
CADTK, CAKB, CAKbeta, E430023O05Rik, FADK2, FAK2, PYK2, Raftk
PTK2 protein tyrosine kinase 2 beta
GO Process (72)
GO Function (8)
GO Component (18)
Gene Ontology Biological Process
- MAPK cascade [ISO]
- actin filament organization [ISO]
- activation of Janus kinase activity [ISO]
- activation of Rac GTPase activity [ISO]
- angiogenesis [ISO]
- blood vessel endothelial cell migration [ISO]
- bone resorption [IMP]
- cell adhesion [ISO]
- cell surface receptor signaling pathway [ISO]
- cellular defense response [ISO]
- cellular response to retinoic acid [ISO]
- chemokine-mediated signaling pathway [IMP]
- epidermal growth factor receptor signaling pathway [IBA, ISO]
- focal adhesion assembly [ISO]
- innate immune response [IBA]
- integrin-mediated signaling pathway [ISO]
- ionotropic glutamate receptor signaling pathway [ISO]
- long-term synaptic potentiation [ISO]
- marginal zone B cell differentiation [IMP]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of bone mineralization [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of muscle cell apoptotic process [ISO]
- negative regulation of myeloid cell differentiation [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of ossification [ISO]
- negative regulation of potassium ion transport [ISO]
- neuron projection development [ISO]
- oocyte maturation [ISO]
- peptidyl-tyrosine autophosphorylation [IBA, ISO]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of B cell chemotaxis [IMP]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of JNK cascade [ISO]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of angiogenesis [IMP]
- positive regulation of cell growth [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [IMP, ISO]
- positive regulation of cell-matrix adhesion [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of endothelial cell migration [IMP, ISO]
- positive regulation of excitatory postsynaptic membrane potential [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of nitric-oxide synthase activity [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of protein kinase activity [IMP, ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of synaptic transmission, glutamatergic [ISO]
- positive regulation of translation [ISO]
- protein phosphorylation [IDA]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISO]
- regulation of actin cytoskeleton reorganization [IMP]
- regulation of cGMP biosynthetic process [IMP]
- regulation of cGMP-mediated signaling [IMP]
- regulation of calcium-mediated signaling [IMP]
- regulation of cell adhesion [IBA, ISO]
- regulation of cell shape [IMP, ISO]
- regulation of establishment of cell polarity [IMP]
- regulation of inositol trisphosphate biosynthetic process [IMP]
- regulation of macrophage chemotaxis [IMP]
- regulation of nitric oxide biosynthetic process [IMP]
- regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- regulation of release of sequestered calcium ion into cytosol [IMP]
- response to hydrogen peroxide [ISO]
- sprouting angiogenesis [IMP]
- stress fiber assembly [ISO]
- tumor necrosis factor-mediated signaling pathway [ISO]
- vascular endothelial growth factor receptor signaling pathway [IMP, ISO]
Gene Ontology Molecular Function- 3-phosphoinositide-dependent protein kinase binding [ISO]
- N-methyl-D-aspartate selective glutamate receptor activity [ISO]
- calmodulin-dependent protein kinase activity [ISO]
- non-membrane spanning protein tyrosine kinase activity [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase activity [IDA]
- receptor binding [IBA]
- 3-phosphoinositide-dependent protein kinase binding [ISO]
- N-methyl-D-aspartate selective glutamate receptor activity [ISO]
- calmodulin-dependent protein kinase activity [ISO]
- non-membrane spanning protein tyrosine kinase activity [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase activity [IDA]
- receptor binding [IBA]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [ISO]
- apical dendrite [ISO]
- axon [ISO]
- cell body [ISO]
- cell cortex [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- dendrite [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- focal adhesion [ISO]
- growth cone [ISO]
- lamellipodium [ISO]
- membrane raft [ISO]
- neuronal cell body [ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- postsynaptic density [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.794 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID